Department of Infectious Diseases, Military Medical Academy, 1606 Sofia, Bulgaria.
Center of Transfusion Hematology, Military Medical Academy, 1606 Sofia, Bulgaria.
Viruses. 2021 Mar 16;13(3):492. doi: 10.3390/v13030492.
Hepatitis E virus (HEV) infection is widespread among domestic pigs, industrial swine, and wild boars in Bulgaria. The aim of the current research was to present the HEV seroprevalence among blood donors in Bulgaria. In the present study, 555 blood donors (479 males and 76 females) were enrolled from five districts in the country (Shumen, Pleven, Stara Zagora, Plovdiv, and Sofia districts). All blood samples were tested for anti-HEV IgG using the Well HEV IgG ELISA test (Mikrogen GmbH, Neuried, Germany). Each participating donor completed a short, structured, and specific questionnaire to document data on the current study. Anti-HEV IgG positive results were detected in 144 (25.9%) blood donors, including 129 (26.9%) males and 15 (19.7%) females. The established HEV seropositivity was 28.8% (23/80) in Shumen district, 23.2% (22/95) in Pleven district, 27.1% (38/140) in Stara Zagora district, 27.5% (44/160) in Plovdiv district, and 21.3% (17/80) in Sofia district. A high HEV seroprevalence was found for persons who declared that they were general hunters (48.7%; 19/39; = 0.001) and hunters of wild boars (51.6%; 16/31; = 0.001). We present the first seroprevalence rates of HEV infection in blood donors from Bulgaria. The results of our research showed high HEV seropositivity among blood donors.
戊型肝炎病毒 (HEV) 感染在保加利亚的家猪、工业猪和野猪中广泛存在。本研究的目的是介绍保加利亚献血者中的 HEV 血清流行率。在本研究中，从该国五个地区（舒门、普列文、斯塔拉扎戈拉、普罗夫迪夫和索非亚地区）招募了 555 名献血者（479 名男性和 76 名女性）。所有血液样本均使用 Well HEV IgG ELISA 测试（Mikrogen GmbH，德国 Neuried）检测抗-HEV IgG。每位参与的献血者都填写了一份简短、结构化和特定的问卷，以记录与本研究相关的数据。在 144 名（25.9%）献血者中检测到抗-HEV IgG 阳性结果，包括 129 名（26.9%）男性和 15 名（19.7%）女性。舒门地区的 HEV 血清阳性率为 28.8%（23/80），普列文地区为 23.2%（22/95），斯塔拉扎戈拉地区为 27.1%（38/140），普罗夫迪夫地区为 27.5%（44/160），索非亚地区为 21.3%（17/80）。结果表明，声明自己是普通猎人（48.7%；19/39； = 0.001）和野猪猎人（51.6%；16/31； = 0.001）的人 HEV 血清阳性率较高。我们呈现了保加利亚献血者中首次 HEV 感染的血清流行率。我们的研究结果表明，献血者中的 HEV 血清阳性率较高。
