Suša Romana, Ćupurdija Vojislav, Novković Ljiljana, Ratinac Miloš, Janković Slobodan, Đoković Danijela, Jovanović Jovan, Pantić Katarina, Simović Stefan, Bazić-Sretenović Danijela, Čekerevac Ivan
Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Clinic for Pulmonology, University Clinical Center Kragujevac, 34000 Kragujevac, Serbia.
Medicina (Kaunas). 2021 Mar 22;57(3):292. doi: 10.3390/medicina57030292.
: This paper aims to show whether obstructive sleep apnea (OSA) severity increases the level of systemic inflammation markers regardless of body mass index (BMI) and body composition. : In total, 128 patients with OSA were included in the study. Examinees were divided into two groups: one with mild OSA (apnea-hypopnea index (AHI) < 15) and one with moderate and severe OSA (AHI ≥ 15). Nutritional status was assessed using body mass index, body composition by dual X-ray absorptiometry. Systemic inflammation was assessed on the basis of plasma concentrations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and serum level of C-reactive protein (CRP). : We found elevated mean values of the evaluated systemic inflammation markers (CRP, TNF-α, IL-6) in a group with AHI ≥ 15, although there was no statistical significance. Our research found a significant positive correlation with BMI ( = 0.633, < 0.001), as well as with body fat percentage ( = 0.450, = 0.024) and serum CRP values. Significant correlation was found between the plasma IL-6 concentration and body fat percentage (FM%) ( = 0.579, = 0.003) and lean body mass ( = -0.501, = 0.013). Multivariate regression analysis did not show any independent predictor (parameters of OSA, nutritional status, body composition) of the systemic inflammation markers. : Neither one tested parameter (nutritional status and body composition) of the severity of OSA was identified as an independent prognostic factor for the severity of systemic inflammation in patients with OSA.
本文旨在表明，无论体重指数（BMI）和身体成分如何，阻塞性睡眠呼吸暂停（OSA）的严重程度是否会增加全身炎症标志物的水平。
该研究共纳入了128例OSA患者。受试者被分为两组：一组为轻度OSA（呼吸暂停低通气指数（AHI）<15），另一组为中度和重度OSA（AHI≥15）。使用体重指数评估营养状况，通过双能X线吸收法评估身体成分。基于肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）的血浆浓度以及C反应蛋白（CRP）的血清水平评估全身炎症。
我们发现，在AHI≥15的组中，所评估的全身炎症标志物（CRP、TNF-α、IL-6）的平均值有所升高，尽管没有统计学意义。我们的研究发现，其与BMI（r = 0.633，P < 0.001）、体脂百分比（r = 0.450，P = 0.024）以及血清CRP值之间存在显著正相关。血浆IL-6浓度与体脂百分比（FM%）（r = 0.579，P = 0.003）和去脂体重（r = -0.501，P = 0.013）之间存在显著相关性。多变量回归分析未显示全身炎症标志物的任何独立预测因素（OSA参数、营养状况、身体成分）。
OSA严重程度的两个测试参数（营养状况和身体成分）均未被确定为OSA患者全身炎症严重程度的独立预后因素。
