Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA.
Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI 02881, USA.
Cells. 2021 Mar 22;10(3):702. doi: 10.3390/cells10030702.
Neurodegenerative disorders are desperately lacking treatment options. It is imperative that drug repurposing be considered in the fight against neurodegenerative diseases. Fenamates have been studied for efficacy in treating several neurodegenerative diseases. The purpose of this review is to comprehensively present the past and current research on fenamates in the context of neurodegenerative diseases with a special emphasis on tolfenamic acid and Alzheimer's disease. Furthermore, this review discusses the major molecular pathways modulated by fenamates.
神经退行性疾病的治疗方法严重匮乏。在对抗神经退行性疾病的过程中，必须考虑药物再利用。芬那酸类药物已被研究用于治疗几种神经退行性疾病。本综述的目的是全面介绍过去和目前关于神经退行性疾病中芬那酸类药物的研究，特别强调托芬那酸和阿尔茨海默病。此外，本综述还讨论了芬那酸类药物调节的主要分子途径。
