The Key Laboratory of High-Altitude Medical Application of Qinghai Province, Qinghai, Xining, 810001, China; Department of Basic Medicine, Medical College of Qinghai University, Qinghai, Xining, 810001, China.
Department of Basic Medicine, Medical College of Qinghai University, Qinghai, Xining, 810001, China.
Biomed Pharmacother. 2021 May;137:111253. doi: 10.1016/j.biopha.2021.111253. Epub 2021 Feb 2.
With a large and increasing elderly population, neurodegenerative diseases such as Parkinson's disease (PD), Huntington disease (HD), Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS) and Multiple sclerosis (MS) have become a major and growing health problem. During the past few decades, the elderly population has grown 2.5 % every year. Unfortunately, there are no specific therapeutic remedies available to slow the onset or development of these diseases. An aging brain causes many pathophysiological changes and is the major risk factor for most of the neurodegenerative disorders. Polyphenolic compounds such as flavonols have shown therapeutic potential and can contribute to the treatment of these diseases. In this review, evidence for the beneficial neuroprotective effect of multiple flavonols is discussed and their multifactorial cellular pathways for the progressions of age-associated brain changes are identified. Moreover, the animal models of these diseases support the neuroprotective effect and target the potential of flavonols in the treatment of neurodegenerative diseases.
随着老年人口的不断增加和老龄化，神经退行性疾病如帕金森病（PD）、亨廷顿病（HD）、阿尔茨海默病（AD）、肌萎缩侧索硬化症（ALS）和多发性硬化症（MS）已成为一个主要且日益严重的健康问题。在过去的几十年中，老年人口每年增长 2.5%。不幸的是，目前尚无特定的治疗方法可以减缓这些疾病的发生或发展。衰老的大脑会导致许多病理生理变化，是大多数神经退行性疾病的主要危险因素。多酚化合物，如类黄酮，已显示出治疗潜力，并有助于治疗这些疾病。在这篇综述中，讨论了多种类黄酮的有益神经保护作用的证据，并确定了它们在与年龄相关的大脑变化进展中的多因素细胞途径。此外，这些疾病的动物模型支持类黄酮的神经保护作用，并针对类黄酮在治疗神经退行性疾病中的潜力。
