MoBioFood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
Nutrients. 2021 Mar 26;13(4):1084. doi: 10.3390/nu13041084.
The endocrine pancreas plays a key role in metabolism. Procyanidins (GSPE) targets β-cells and glucagon-like peptide-1 (GLP-1)-producing cells; however, there is no information on the effects of GSPE on glucagon. We performed GSPE preventive treatments administered to Wistar rats before or at the same time as they were fed a cafeteria diet during 12 or 17 weeks. We then measured the pancreatic function and GLP-1 production. We found that glucagonemia remains modified by GSPE pre-treatment several weeks after the treatment has finished. The animals showed a higher GLP-1 response to glucose stimulation, together with a trend towards a higher GLP-1 receptor expression in the pancreas. When the GSPE treatment was administered every second week, the endocrine pancreas behaved differently. We show here that glucagon is a more sensitive parameter than insulin to GSPE treatments, with a secretion that is highly linked to GLP-1 ileal functionality and dependent on the type of treatment.
内分泌胰腺在新陈代谢中起着关键作用。原花青素（GSPE）的作用靶点是β细胞和胰高血糖素样肽-1（GLP-1）分泌细胞；然而，目前还没有关于 GSPE 对胰高血糖素影响的信息。我们对 Wistar 大鼠进行了 GSPE 预防性治疗，在给予 cafeteria 饮食的同时或之前进行治疗，持续 12 或 17 周。然后，我们测量了胰腺功能和 GLP-1 的产生。我们发现，在治疗结束数周后，胰高血糖素血症仍受 GSPE 预处理的影响。动物对葡萄糖刺激的 GLP-1 反应更高，同时胰腺中的 GLP-1 受体表达也呈上升趋势。当每隔一周进行 GSPE 治疗时，内分泌胰腺的表现则不同。我们在这里表明，与胰岛素相比，胰高血糖素对 GSPE 治疗更为敏感，其分泌与 GLP-1 回肠功能高度相关，并且取决于治疗类型。
