Stene-Larsen G, Weberg R, Frøyshov Larsen I, Bjørtuft O, Hoel B, Berstad A
Medical Dept., Lovisenberg Hospital, Oslo, Norway.
Scand J Gastroenterol. 1988 May;23(4):427-32. doi: 10.3109/00365528809093890.
In a prospective study in 1224 patients referred for upper alimentary endoscopy, reflux oesophagitis was found in 195 (16%) of the patients and hiatus hernia in 249 (20%). In patients with reflux oesophagitis a coexisting hiatus hernia was found in 68%. The weight-for-height index (W/H1.8), which expresses the degree of overweight, was significantly higher both in patients with hiatus hernia and in the patients with reflux oesophagitis, indicating an overweight of approximately 5% in both groups. The overweight was most pronounced in oesophagitis grades 1 and 2, whereas in patients with severe oesophagitis (grade 3) body weight was normal, possibly owing to weight loss caused by dysphagia and excessive regurgitation. The results support the view that adiposity is associated with both sliding hiatus hernia and reflux oesophagitis and that hiatus hernia plays a role in the development of reflux oesophagitis.
在一项针对1224例接受上消化道内镜检查患者的前瞻性研究中，195例（16%）患者发现有反流性食管炎，249例（20%）患者发现有食管裂孔疝。在反流性食管炎患者中，68%同时存在食管裂孔疝。表示超重程度的身高体重指数（W/H1.8）在食管裂孔疝患者和反流性食管炎患者中均显著更高，表明两组患者超重约5%。超重现象在1级和2级食管炎患者中最为明显，而在重度食管炎（3级）患者中体重正常，这可能是由于吞咽困难和过度反流导致体重减轻。这些结果支持了肥胖与滑动性食管裂孔疝和反流性食管炎均相关，且食管裂孔疝在反流性食管炎的发生中起作用这一观点。
