Stakishaĭtis D V, Ivashkiavichenie L I, Kameneva A M
Kardiologiia. 1991 Oct;31(10):33-6.
The paper discusses the results from a study into apolipoproteins B (apo-B) and AI (apo-AI) and apoB/apo-AI ratios in the blood of 188 healthy donors and 122 male patients with coronary atherosclerosis. Atherosclerotic lesions were coronary angiographically documented. The study was performed (in two age groups of patients: 1) those under 45 years and 2) those over 45 years. A relationship was examined between the levels of apolipoproteins and the lesion of one, two, three or more coronary arteries in the two age groups. The studies indicate that there are various mechanisms responsible for the pathogenesis of atherosclerosis in the age groups in question. It is concluded that the younger a patient is, the higher probability that elevated blood apo-B levels are essential in the pathogenesis of coronary atherosclerosis is. Determination of plasma apo-B and apo-AI levels and apo-B/apo-AI ratios enables a potential number of diseased coronary arteries to be predicted.
该论文讨论了一项针对188名健康献血者和122名患有冠状动脉粥样硬化的男性患者血液中的载脂蛋白B（apo - B）、载脂蛋白AI（apo - AI）以及apoB/apo - AI比值的研究结果。动脉粥样硬化病变通过冠状动脉造影记录。该研究在两个年龄组的患者中进行：1）45岁以下的患者；2）45岁以上的患者。研究了两个年龄组中载脂蛋白水平与一根、两根、三根或更多冠状动脉病变之间的关系。研究表明，在所研究的年龄组中，动脉粥样硬化的发病机制存在多种因素。得出的结论是，患者年龄越小，血液中apo - B水平升高在冠状动脉粥样硬化发病机制中起关键作用的可能性就越高。测定血浆apo - B和apo - AI水平以及apoB/apo - AI比值能够预测可能患病的冠状动脉数量。
