Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Hospital Universitário da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
J Glob Antimicrob Resist. 2021 Jun;25:199-201. doi: 10.1016/j.jgar.2021.03.018. Epub 2021 Apr 1.
Candida tropicalis is one of the three most frequent species causing candidaemia in Latin America. Despite the high prevalence of C. tropicalis in candidaemia cases in Brazil, little is known about the trends in fluconazole susceptibility over time. The objective of this study was to evaluate temporal trends in azole resistance rates among C. tropicalis bloodstream isolates from patients treated in six Brazilian medical centres over a 12-year period.
We selected 200 C. tropicalis bloodstream isolates from six medical centres in Brazil collected between 2007 and 2018. Species identification was confirmed by MALDI-TOF/MS. Antifungal susceptibility testing for four antifungal agents was performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method.
Overall, rates of non-susceptibility were 4% and 3.5% to fluconazole and voriconazole, respectively. All isolates were susceptible to amphotericin B and only one isolate was resistant to echinocandins.
Although we failed to demonstrate statistical differences in the rates of azole resistance documented during the period of analysis, trends towards lower susceptibility to fluconazole and voriconazole were shown.
热带假丝酵母菌是拉丁美洲引起念珠菌血症的三种最常见菌种之一。尽管巴西念珠菌血症病例中热带假丝酵母菌的流行率很高，但关于氟康唑敏感性随时间变化的趋势知之甚少。本研究的目的是评估在巴西 6 家医疗中心治疗的患者中，12 年间热带假丝酵母菌血流感染分离株唑类耐药率的时间趋势。
我们从巴西 6 家医疗中心于 2007 年至 2018 年间收集的 200 株热带假丝酵母菌血流感染分离株中进行了选择。通过 MALDI-TOF/MS 确认菌种鉴定。采用临床和实验室标准化研究所（CLSI）微量肉汤法对四种抗真菌药物进行抗真菌药敏试验。
总体而言，氟康唑和伏立康唑的不敏感率分别为 4%和 3.5%。所有分离株均对两性霉素 B 敏感，只有 1 株对棘白菌素类药物耐药。
尽管我们未能证明在分析期间记录的唑类耐药率存在统计学差异，但显示出对氟康唑和伏立康唑的敏感性降低的趋势。
