Dept. of Radiology, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Dept. of Laboratory Sciences, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Hum Immunol. 2021 Jun;82(6):446-454. doi: 10.1016/j.humimm.2021.03.008. Epub 2021 Mar 31.
Ionizing radiation, including X and gamma rays, are used for various purposes such as; medicine, nuclear power, research, manufacturing, food preservation and construction. Furthermore, people are also exposed to ionizing radiation from their workplace or the environment. Apart from DNA fragmentation resulting in apoptosis, several additional mechanisms have been proposed to describe how radiation can alter human cell functions. Ionizing radiation may alter immune responses, which are the main cause of human disorders. Toll like receptors (TLRs) are important human innate immunity receptors which participate in several immune and non-immune cell functions including, induction of appropriate immune responses and immune related disorders. Based on the role played by ionizing radiation on human cell systems, it has been hypothesized that radiation may affect immune responses. Therefore, the main aim of this review article is to discuss recent information regarding the effects of ionizing radiation on TLRs and their related disorders.
电离辐射，包括 X 射线和伽马射线，被用于各种目的，如医学、核能、研究、制造、食品保存和建筑。此外，人们还会因工作场所或环境而接触到电离辐射。除了导致细胞凋亡的 DNA 片段化外，还提出了几种额外的机制来描述辐射如何改变人类细胞的功能。电离辐射可能会改变免疫反应，这是人类疾病的主要原因。Toll 样受体（TLR）是重要的人类先天免疫受体，参与多种免疫和非免疫细胞功能，包括诱导适当的免疫反应和与免疫相关的疾病。基于电离辐射对人类细胞系统的作用，有人假设辐射可能会影响免疫反应。因此，本文的主要目的是讨论关于电离辐射对 TLR 及其相关疾病影响的最新信息。
