Department of Immunology, Faculty of Medicine, Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Immunology, Faculty of Medicine, Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Life Sci. 2018 Jun 15;203:105-111. doi: 10.1016/j.lfs.2018.03.040. Epub 2018 Mar 27.
It has been demonstrated that vitamin D (VD) significantly modulates immune responses. Toll like receptors (TLRs) are the main innate immunity receptors which are expressed on the cell membrane and intracellular vesicles and recognize several pathogen associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs) to induce immune responses. Based on the important roles played by TLRs in physiologic and pathologic functions of immune responses and due to the immunomodulatory functions of VD, it has been hypothesized that VD may present its immunomodulatory functions via modulation of TLRs. This review article collates recent studies regarding the interactions between VD and TLRs and discussed the controversial investigations.
已经证明，维生素 D（VD）可显著调节免疫反应。Toll 样受体（TLRs）是主要的先天免疫受体，表达在细胞膜和细胞内小泡上，识别多种病原体相关分子模式（PAMPs）和损伤相关分子模式（DAMPs），以诱导免疫反应。鉴于 TLRs 在免疫反应的生理和病理功能中发挥的重要作用，以及 VD 的免疫调节功能，有人假设 VD 可能通过调节 TLRs 来发挥其免疫调节功能。本文综述了最近关于 VD 与 TLRs 相互作用的研究，并讨论了有争议的研究。
