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CRISPR FokI Dead Cas9 System: Principles and Applications in Genome Engineering.CRISPR FokI Dead Cas9 系统:基因组工程中的原理与应用。
Cells. 2020 Nov 21;9(11):2518. doi: 10.3390/cells9112518.
2
A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells.一项对患有血友病 A 的狗进行的 AAV 基因治疗的长期研究发现,转导的肝细胞发生了克隆扩增。
Nat Biotechnol. 2021 Jan;39(1):47-55. doi: 10.1038/s41587-020-0741-7. Epub 2020 Nov 16.
3
Benchmarking and integrating genome-wide CRISPR off-target detection and prediction.基因组范围的 CRISPR 脱靶检测和预测的基准测试和整合。
Nucleic Acids Res. 2020 Nov 18;48(20):11370-11379. doi: 10.1093/nar/gkaa930.
4
Detection of CRISPR/Cas9-Generated Off-Target Effect by Integration-Defective Lentiviral Vector.通过整合缺陷型慢病毒载体检测 CRISPR/Cas9 产生的脱靶效应。
Methods Mol Biol. 2021;2162:243-260. doi: 10.1007/978-1-0716-0687-2_14.
5
Translational Potential of Immune Tolerance Induction by AAV Liver-Directed Factor VIII Gene Therapy for Hemophilia A.AAV 肝靶向因子 VIII 基因治疗诱导免疫耐受治疗血友病 A 的转化潜力。
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RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.靶向血管紧张素原的RNA干扰疗法可改善啮齿动物模型中的子痫前期表型。
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CRISPR/Cas9 介导的血管紧张素原基因缺失可降低高血压:有治愈的可能吗?

CRISPR/Cas9 Mediated Deletion of the Angiotensinogen Gene Reduces Hypertension: A Potential for Cure?

机构信息

Mandel Center and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC.

出版信息

Hypertension. 2021 Jun;77(6):1990-2000. doi: 10.1161/HYPERTENSIONAHA.120.16870. Epub 2021 Apr 5.

DOI:10.1161/HYPERTENSIONAHA.120.16870
PMID:33813849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9896968/
Abstract

[Figure: see text].

摘要

[图:见正文]。