Steiner G C, Kantor E B
Cancer. 1977 Dec;40(6):2967-78. doi: 10.1002/1097-0142(197712)40:6<2967::aid-cncr2820400632>3.0.co;2-i.
The ultrastructure of 5 cases of primary aneurysmal bone cysts is described. The most frequent cells found are fibroblasts containing varying amounts of glycogen. Primitive mesenchymal cells in different stages of differentiation are seen. The foci of osteoid and bone originate through metaplastic changes of the spindle cell stroma. We feel that the fibroblastic proliferation and bone formation are manifestations of a reactive process. The giant cells are similar to those of other giant cell lesions of bone. A case of cystic chondroblastoma with secondary aneurysmal bone cyst features was studied. It shows, in addition to chondroblastoma cells, elongated cells similar to the reactive fibroblasts of primary aneurysmal bone cyst. We feel that aneurysmal bone cyst is a benign non-neoplastic condition that can develop in bone as a primary bone lesion; it may also be associated with a pre-neoplastic condition that can develop in bone as a primary bone lesion; it may also be associated with a pre-existing bone condition, and occasionally develops following trauma with subperiosteal hematoma.
本文描述了5例原发性动脉瘤样骨囊肿的超微结构。最常见的细胞是含有不同量糖原的成纤维细胞。可见处于不同分化阶段的原始间充质细胞。类骨质和骨灶起源于梭形细胞基质的化生改变。我们认为成纤维细胞增殖和骨形成是一种反应性过程的表现。巨细胞与骨的其他巨细胞病变中的巨细胞相似。研究了1例具有继发性动脉瘤样骨囊肿特征的囊性软骨母细胞瘤。除软骨母细胞瘤细胞外，还可见到与原发性动脉瘤样骨囊肿的反应性成纤维细胞相似的细长细胞。我们认为动脉瘤样骨囊肿是一种良性非肿瘤性疾病，可作为原发性骨病变在骨内发生；它也可能与一种可作为原发性骨病变在骨内发生的肿瘤前状态有关；它还可能与先前存在的骨病有关，偶尔在伴有骨膜下血肿的创伤后发生。
