基于苦参炭的碳点对乙醇诱导的大鼠急性胃溃疡的保护作用：抗炎和抗氧化活性。

Protective Effects of Radix Sophorae Flavescentis Carbonisata-Based Carbon Dots Against Ethanol-Induced Acute Gastric Ulcer in Rats: Anti-Inflammatory and Antioxidant Activities.

机构信息

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.

School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.

出版信息

Int J Nanomedicine. 2021 Mar 26;16:2461-2475. doi: 10.2147/IJN.S289515. eCollection 2021.

AIM

To explore the effects of Radix Sophorae Flavescentis carbonisata-based carbon dots (RSFC-CDs) on an ethanol-induced acute gastric ulcer rat model.

METHODS

The structure, optical properties, functional groups and elemental composition of RSFC-CDs synthesized by one-step pyrolysis were characterized. The gastric protective effects of RSFC-CDs were evaluated and confirmed by applying a rat model of ethanol-induced acute gastric ulcers. The underlying mechanisms were investigated through the nuclear factor-kappa B (NF-κB) signalling pathway and oxidative stress.

RESULTS

RSFC-CDs with a diameter ranging from 2-3 nm mainly showed gastric protective effects by reducing the levels of NF-κB, tumour necrosis factor-α (TNF-α), interleukin (IL)-6, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione (GSH), malondialdehyde (MDA) and inducible nitric oxide synthase (iNOS) to inhibit ethanol-induced inflammation and oxidative stress.

CONCLUSION

RSFC-CDs have anti-inflammatory and anti-oxidative effects, making them promising for application in ethanol-induced gastric injury.

目的

探讨苦参炭基碳点（RSFC-CDs）对乙醇诱导的急性胃溃疡大鼠模型的影响。

方法

采用一步热解法合成 RSFC-CDs，对其结构、光学性质、官能团和元素组成进行了表征。通过乙醇诱导的急性胃溃疡大鼠模型，评价和证实了 RSFC-CDs 的胃保护作用。通过核因子-κB（NF-κB）信号通路和氧化应激探讨其作用机制。

结果

RSFC-CDs 的直径为 2-3nm，主要通过降低 NF-κB、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）、谷胱甘肽（GSH）、丙二醛（MDA）和诱导型一氧化氮合酶（iNOS）的水平，抑制乙醇诱导的炎症和氧化应激，从而发挥胃保护作用。