Department of Advanced Biomedical Sciences, Federico II University of Naples, Italy.
Department of Medicine, Wilf Family Cardiovascular Research Institute, Einstein-Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
Oxid Med Cell Longev. 2021 Mar 15;2021:6684568. doi: 10.1155/2021/6684568. eCollection 2021.
Ergogenic nutritional supplementation is sought by professional athletes for improving physical performance; nevertheless, scientific evidence to support the chronic use of L-Arginine among water polo players is missing.
Seventeen male professional water polo players were randomly assigned to assume 5 grams per day of L-Arginine ( = 9) or placebo ( = 8) for 4 weeks. The players' fitness level was assessed in the maximal speed swimming test. Ear lobe blood samples taken before and after the effort for serum lactate content were analyzed. A speed-to-lactate ratio was generated at the baseline and after 4 weeks of treatment. We also tested the effects of L-Arginine , measuring NO production, mitochondrial respiration, and gene expression in human fibroblasts.
L-Arginine did not modify BMI, muscle strength, and maximal speed at 200 meters after 4 weeks. However, L-Arginine ameliorated oxidative metabolism to exercise as suggested by the statistically significant lower lactate-to-speed ratio, which was not observed in placebo-treated controls. , L-Arginine induced the expression of a key regulator of mitochondrial biogenesis (PGC1) and genes encoding for complex I and increased the production of nitric oxide and the maximal oxygen consumption rate.
Chronic L-Arginine is safe and effective in ameliorating the oxidative metabolism of professional water polo players, through a mechanism of enhanced mitochondrial function.
专业运动员寻求有益的营养补充剂来提高运动表现；然而，目前缺乏关于在水球运动员中长期使用精氨酸的科学证据。
17 名男性职业水球运动员被随机分配每天服用 5 克精氨酸（= 9 人）或安慰剂（= 8 人），持续 4 周。使用最大速度游泳测试评估运动员的体能水平。分析运动前后耳血样中的血清乳酸含量。在基线和 4 周治疗后生成速度与乳酸比值。我们还测试了精氨酸对人成纤维细胞中 NO 产生、线粒体呼吸和基因表达的影响。
精氨酸在 4 周后并未改变 BMI、肌肉力量和 200 米最大速度。然而，精氨酸改善了运动时的氧化代谢，这一点可以从统计学上显著更低的乳酸与速度比值中看出，而安慰剂治疗组则没有观察到这种情况。此外，精氨酸诱导了线粒体生物发生的关键调节因子（PGC1）和编码复合物 I 的基因的表达，并增加了一氧化氮的产生和最大耗氧量。
慢性精氨酸补充安全且有效，可通过增强线粒体功能改善专业水球运动员的氧化代谢。
