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伴有门静脉瘤栓和多灶性肝转移的导管内乳头状黏液性癌：1例尸检病例

Intraductal papillary-mucinous carcinoma with portal vein tumor thrombus and multifocal liver metastasis: An autopsy case.

作者信息

Matsushita Naohiro, Douhara Akitoshi, Ueno Hirotsugu, Asada Shohei, Murata Koji, Yanase Koji, Tsutsumi Masahiro

机构信息

Clinical Study and Training Center, Saiseikai Chuwa Hospital, Sakurai, Nara 633-0054, Japan.

Department of Gastroenterology, Saiseikai Chuwa Hospital, Sakurai, Nara 633-0054, Japan.

出版信息

Mol Clin Oncol. 2021 May;14(5):101. doi: 10.3892/mco.2021.2263. Epub 2021 Mar 13.

DOI:10.3892/mco.2021.2263
PMID:33815792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8015015/
Abstract

The prognosis of intraductal papillary-mucinous neoplasm is superior to that of conventional pancreatic ductal adenocarcinoma. Only a few advanced cases of intraductal papillary-mucinous carcinoma (IPMC) have been reported to date. We herein report the case of a 78-year-old male patient with advanced pancreatobiliary type IPMC with portal vein invasion and liver metastasis. The IPMC invaded the portal vein to form a tumor thrombus and it also metastasized to the liver via the portal vein. After receiving best supportive care, the patient succumbed to the disease following an exacerbation of IPMC 90 days after the initial presentation. On autopsy, a very long tumor thrombus was identified, along with liver metastatic lesions, which had retained the structure of the primary IPMC on histological examination.

摘要

导管内乳头状黏液性肿瘤的预后优于传统的胰腺导管腺癌。迄今为止，仅报道了少数导管内乳头状黏液癌（IPMC）晚期病例。我们在此报告一例78岁男性患者，患有伴有门静脉侵犯和肝转移的晚期胰胆管型IPMC。IPMC侵犯门静脉形成肿瘤血栓，并通过门静脉转移至肝脏。在接受最佳支持治疗后，患者在初次就诊90天后因IPMC病情加重而死亡。尸检时，发现了一条很长的肿瘤血栓以及肝脏转移灶，组织学检查显示其保留了原发性IPMC的结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/ea1540cbfefc/mco-14-05-02263-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/095a055f7032/mco-14-05-02263-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/c86856e71140/mco-14-05-02263-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/5158d25b86e9/mco-14-05-02263-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/fd62629f0f51/mco-14-05-02263-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/920e121bb4e3/mco-14-05-02263-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/ea1540cbfefc/mco-14-05-02263-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/095a055f7032/mco-14-05-02263-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/c86856e71140/mco-14-05-02263-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/5158d25b86e9/mco-14-05-02263-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/fd62629f0f51/mco-14-05-02263-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/920e121bb4e3/mco-14-05-02263-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a8/8015015/ea1540cbfefc/mco-14-05-02263-g05.jpg

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本文引用的文献

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胰腺内导管乳头状黏液性肿瘤（IPMN）切除术后的复发模式；日本胰腺学会对 1074 例 IPMN 患者的多中心回顾性研究。
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