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新型精神药物贝米替尔在治疗虚弱症中的应用(临床药理学研究)

[Use of the new psychotropic preparation bemitil in treating asthenic disorders (clinico-pharmacological research)].

作者信息

Aleksandrovskiĭ Iu A, Bobkov Iu G, Neznamov G G, Serebriakova T V, Boĭko S S

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(3):109-15.

PMID:3381606
Abstract

In a series of 130 patients with asthenic conditions related to borderline forms of neuro-mental disturbances the authors compared clinico-pharmacological action of the actoprotector bemitil with that of nootropic drugs (piracetam and piridotol). The treatment with bemitil was either continuous or intermittent, being conducted according to the scheme elaborated in the course of the study. Bemitil proved to be more effective than piracetam and piriditol in relation to its influence on the manifestations of the asthenic symptom complex in general. Its application was characterized by a faster onset of the therapeutic effect and a peculiar mild psychostimulating action, primarily manifested in the impact on obligate manifestations of the asthenic disorders. The degree of the psychotropic action of the drug was found to be subject to changes depending on the scheme of its use.

摘要

在130例与边缘性神经精神障碍相关的虚弱状态患者中,作者比较了抗疲劳剂贝米替尔与益智药(吡拉西坦和匹立多醇)的临床药理作用。贝米替尔的治疗采用持续或间歇方式,按照研究过程中制定的方案进行。总体而言,贝米替尔在影响虚弱症状复合体表现方面比吡拉西坦和匹立多醇更有效。其应用的特点是治疗效果起效更快,具有独特的轻度精神兴奋作用,主要体现在对虚弱障碍的必然表现的影响上。发现该药物的精神作用程度会根据其使用方案而发生变化。

相似文献

1
[Use of the new psychotropic preparation bemitil in treating asthenic disorders (clinico-pharmacological research)].新型精神药物贝米替尔在治疗虚弱症中的应用(临床药理学研究)
Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(3):109-15.
2
[Pharmacokinetics and the clinical effect of bemitil after a single administration].[单次给药后贝米替尔的药代动力学及临床效应]
Farmakol Toksikol. 1986 Sep-Oct;49(5):17-20.
3
[Experience using nootropil in patients with chronic ischemic heart disease].
Klin Med (Mosk). 1989 May;67(5):36-8.
4
[Changes in the narrow-band components of the EEG spectrum under the action of nootropic drugs].[益智药物作用下脑电图频谱窄带成分的变化]
Eksp Klin Farmakol. 1992 May-Jun;55(3):14-7.
5
[The role of bemitil pharmacokinetics in realizing its therapeutic efficacy].贝米替尔药代动力学在实现其治疗效果中的作用
Farmakol Toksikol. 1991 Mar-Apr;54(2):64-6.
6
[Effect of physostigmine and various nootropic drugs on various mental disorders caused by brain injury].毒扁豆碱及多种益智药物对脑损伤所致各种精神障碍的影响
Psychiatr Pol. 1988 Sep-Oct;22(5):317-21.
7
[Certain principles for differential utilization of metabolic treatment preparations in the complex therapy of mental disorders].
Zh Nevropatol Psikhiatr Im S S Korsakova. 1979;79(8):1077-83.
8
[The effect of nootropic substances on fluctuations in vigilance tonus in postinjury pseudoneurasthenia. EEG study].[促智物质对创伤后假性神经衰弱警觉紧张度波动的影响。脑电图研究]
Cesk Neurol Neurochir. 1985 Jul;48(4):235-9.
9
[Specificity of the action of piracetam, encephabol and Cleregil on the transcallosal evoked potential].
Biull Eksp Biol Med. 1986 Mar;101(3):320-2.
10
[Use of psychotropic drugs in general somatic practice].[精神药物在普通躯体疾病诊疗中的应用]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(4):594-9.

引用本文的文献

1
The pharmacology of actoprotectors: practical application for improvement of mental and physical performance.抗疲劳药物的药理学:改善精神和身体机能的实际应用。
Biomol Ther (Seoul). 2012 Sep;20(5):446-56. doi: 10.4062/biomolther.2012.20.5.446.