Boĭko S S, Bobkov Iu G, Neznamov G G, Serebriakova T V
Farmakol Toksikol. 1986 Sep-Oct;49(5):17-20.
It was found on studying a novel psychotropic drug bemitil that after its single administration kinetic curves significantly differed depending on a clinical effect of the test dose in patients with asthenic states. At predomination of the psychoactivating component of action one could note a larger area under the concentration-time relationship curve and a shorter period of half-excretion than in patients with the tranquilizing action. The obtained data on the difference in the drug test dose effect depending on the drug pharmacokinetics should be taken into consideration at determination of bemitil course therapy duration in patients with neuroses and neurosis-like states with predominance of asthenic disturbances in the clinical picture.
在研究一种新型精神药物贝米替尔时发现，单次给药后，其动力学曲线因衰弱状态患者试验剂量的临床效果不同而有显著差异。与具有镇静作用的患者相比，当药物的精神激活作用占主导时，浓度-时间关系曲线下的面积更大，排泄半衰期更短。在确定神经症和类神经症状态且临床表现以衰弱障碍为主的患者使用贝米替尔的疗程时，应考虑到根据药物药代动力学所获得的关于药物试验剂量效果差异的数据。
