Investigation of The Relationship of Gene Polymorphisms with Breast Cancer Development and Metastasis Risk in Patients with Or Pathogenic Variants Living in The Trakya Region of Turkey.

Modifying genes play an exclusive role in the genetic regulation of the risk of breast cancer development in women with a pathogenic variation of or . Therefore, it has been suggested that , which is among those modifying genes present in breast cancer development, may have a significant role in patients with positive or variations. In our study, we investigated the probable effects of single nucleotide polymorphisms (SNPs) in the gene, such as rs4485469, rs9646629, rs34739845, rs17069904, rs 884205, rs4941129 on the risk of breast cancer in patients with or variations. A total of 23 breast cancer patients with pathogenic variations in the or genes, 28 patients with no pathogenic variations in the or genes, and 55 healthy women as a control group, were included in this study. The SNPs were determined with allelic discrimination analysis through the real-time polymerase chain reaction (qPCR) method. There was no statistically significant difference between the SNPs of the gene rs4485469, rs9646629, rs34739845, rs17069904, rs884205, rs4941129 and metastasis, estrogen receptor, progesterone receptor and CerB2 receptor positivity between patient and control group ( >0.05). However, the rs4485469 SNP was found to be borderline significant between the patient groups with and without or mutations ( = 0.059). In patients with or pathogenic variations living in the Trakya region of Turkey, we could not determine the relationship between SNPs with breast cancer risk.