Mäkinen T, Pekonen F, Franssila K, Lamberg B A
Minerva Foundation Institute for Medical Research, University of Helsinki, Finland.
Acta Endocrinol (Copenh). 1988 Jan;117(1):45-50. doi: 10.1530/acta.0.1170045.
The EGF and TSH receptor properties in malignant thyroid tumours and adjacent normal thyroid tissues were characterized using radioreceptor assays. Ten patients with papillary, 4 with medullary, 1 with Hürthle cell type follicular carcinoma, and 2 with anaplastic thyroid carcinoma were studied. In 10 out of 12 patients with papillary and anaplastic thyroid carcinomas, more EGF receptors were found in the neoplastic tissue than in the adjacent normal tissue (P less than 0.01). The affinity of the EGF receptors varied between patients (from 0.5 X 10(9) l/mol to 1.9 X 10(9) l/mol), but was in each patient the same in the neoplastic and in the normal tissue. In medullary carcinomas and a follicular Hürthle thyroid carcinoma, the EGF receptor content was very low. The receptor number was unaltered or decreased in papillary carcinomas when compared with adjacent normal tissue. In anaplastic medullary and follicular (Hürthle cell) carcinomas, the neoplastic tissue had very few high affinity TSH receptor sites. The alterations in TSH receptor characteristics when thyroid neoplastic tissue was compared with adjacent normal tissue did not correlate to changes in EGF receptor characteristics. Our results demonstrate that the amount of EGF receptors in papillary and anaplastic thyroid carcinomas differ significantly from that in follicular and medullary carcinomas and that alterations in EGF receptor content in malignant thyroid tissues are independent of TSH receptor content.
采用放射受体分析法对恶性甲状腺肿瘤及相邻正常甲状腺组织中的表皮生长因子（EGF）和促甲状腺激素（TSH）受体特性进行了表征。研究了10例乳头状癌、4例髓样癌、1例许特耳细胞型滤泡癌和2例未分化甲状腺癌患者。在12例乳头状癌和未分化甲状腺癌患者中的10例中，肿瘤组织中发现的EGF受体比相邻正常组织中的多（P小于0.01）。EGF受体的亲和力在患者之间有所不同（从0.5×10⁹ l/mol到1.9×10⁹ l/mol），但在每个患者的肿瘤组织和正常组织中是相同的。在髓样癌和滤泡性许特耳甲状腺癌中，EGF受体含量非常低。与相邻正常组织相比，乳头状癌中的受体数量未改变或减少。在未分化髓样癌和滤泡性（许特耳细胞）癌中，肿瘤组织中高亲和力TSH受体位点很少。当将甲状腺肿瘤组织与相邻正常组织进行比较时，TSH受体特性的改变与EGF受体特性的变化不相关。我们的结果表明，乳头状癌和未分化甲状腺癌中EGF受体的数量与滤泡癌和髓样癌中的有显著差异，并且恶性甲状腺组织中EGF受体含量的改变与TSH受体含量无关。
