Akslen L A, Myking A O, Salvesen H, Varhaug J E
Department of Pathology, Gade Institute, Bergen, Norway.
Br J Cancer. 1993 Oct;68(4):808-12. doi: 10.1038/bjc.1993.432.
In this study of papillary thyroid carcinomas, immunopositivity for EGF-receptor was present in a majority of the cases (96%), although different staining patterns were observed. A distinct membraneous reaction was found in 46%, whereas cytoplasmatic positivity of various degrees was present in 90% of the cases. Strong cytoplasmic EGF-receptor staining was significantly associated with extra-thyroidal growth of the primary tumour (P = 0.009), and it was furthermore related to decreased recurrence free survival (P = 0.006). Membraneous EGF-receptor staining was not associated with recurrence free survival or patient survival. Multivariate Cox analysis showed that lymph node metastases (P = 0.0009) and cytoplasmic EGF-receptor staining (P = 0.0048) was independent indicators of tumour recurrences in this group of surgically treated papillary thyroid carcinomas.
在这项关于甲状腺乳头状癌的研究中，尽管观察到不同的染色模式，但大多数病例（96%）中存在表皮生长因子受体免疫阳性。46%的病例中发现有明显的膜反应，而90%的病例存在不同程度的细胞质阳性。强烈的细胞质表皮生长因子受体染色与原发性肿瘤的甲状腺外生长显著相关（P = 0.009），此外还与无复发生存率降低有关（P = 0.006）。膜表皮生长因子受体染色与无复发生存率或患者生存率无关。多变量Cox分析显示，在这组接受手术治疗的甲状腺乳头状癌中，淋巴结转移（P = 0.0009）和细胞质表皮生长因子受体染色（P = 0.0048）是肿瘤复发的独立指标。
