Nakamura M, Saito H, Kasanuki J, Tamura Y, Yoshida S
Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
Gut. 1992 Jul;33(7):933-7. doi: 10.1136/gut.33.7.933.
The production of cytokines in peripheral blood mononuclear leukocytes of patients with inflammatory bowel disease was investigated. T cell subset analysis and differential white blood cell counts were also performed. Thirty five patients with ulcerative colitis, 14 with Crohn's disease, and 15 age matched healthy volunteers were studied. No differences were observed in T cell subsets and OKT4/OKT8 ratios in patients with ulcerative colitis or Crohn's disease compared with controls. Interleukin 1 beta production was significantly increased in active ulcerative colitis and Crohn's disease, compared with values in controls, but returned to control levels in the inactive stages. In addition, in active ulcerative colitis and Crohn's disease, there were significant correlations between the interleukin 1 beta production and the ulcerative colitis activity index or Crohn's disease activity index. Interleukin 2 production was also significantly increased in the active ulcerative colitis and significantly correlated to the activity index, but there was no change in Crohn's disease patients compared with controls. Gamma interferon production in patients was the same as that in controls. This study suggests that the interleukin 1 beta and 2 values in peripheral mononuclear leukocytes of active untreated inflammatory bowel disease are indicators of the disease states of ulcerative colitis or Crohn's disease, or both.
对炎症性肠病患者外周血单核白细胞中细胞因子的产生进行了研究。还进行了T细胞亚群分析和白细胞分类计数。研究了35例溃疡性结肠炎患者、14例克罗恩病患者和15名年龄匹配的健康志愿者。与对照组相比，溃疡性结肠炎或克罗恩病患者的T细胞亚群和OKT4/OKT8比值未观察到差异。与对照组相比，活动期溃疡性结肠炎和克罗恩病患者白细胞介素1β的产生显著增加，但在非活动期恢复到对照水平。此外，在活动期溃疡性结肠炎和克罗恩病中，白细胞介素1β的产生与溃疡性结肠炎活动指数或克罗恩病活动指数之间存在显著相关性。活动期溃疡性结肠炎患者白细胞介素2的产生也显著增加，且与活动指数显著相关，但克罗恩病患者与对照组相比无变化。患者γ干扰素的产生与对照组相同。这项研究表明，未经治疗的活动期炎症性肠病患者外周单核白细胞中白细胞介素1β和2的值是溃疡性结肠炎或克罗恩病或两者疾病状态的指标。
