兔骨基质可诱导无胸腺大鼠的骨形成。

Rabbit bone matrix induces bone formation in the athymic rat.

作者信息

Aspenberg P, Thorngren K G, Lohmander L S

机构信息

Lund University Department of Orthopedics, Sweden.

出版信息

Acta Orthop Scand. 1988 Jun;59(3):276-8. doi: 10.3109/17453678809149362.

DOI:10.3109/17453678809149362

PMID:3381658

Abstract

Rabbit and rat bone matrix were implanted in athymic rat muscle, and the bone yield was measured as total calcium content after 4, 6, and 8 weeks. Matrix from both species induced equal amounts of new bone in the athymic rat. In rabbit and normal rat, the xenogenic matrix induced little or no bone formation. Thus, in the case of rabbit and rat, bone induction is species specific due to immunogenic mechanisms. The athymic rat can be used to measure inductive properties of bone matrix from different species.

摘要

将兔和大鼠的骨基质植入无胸腺大鼠的肌肉中，并在4周、6周和8周后将骨产量测定为总钙含量。来自这两个物种的基质在无胸腺大鼠中诱导出等量的新骨。在兔和正常大鼠中，异种基质诱导很少或不发生骨形成。因此，就兔和大鼠而言，由于免疫原性机制，骨诱导具有物种特异性。无胸腺大鼠可用于测量不同物种骨基质的诱导特性。