Yu Jung Re, Lee Sang Ah, Lee Jae-Geun, Seong Gil Myeong, Ko Seong Joo, Koh Gwanpyo, Kong Mi-Hee, Park Keun-Young, Kim Byung-Joon, Lim Dong-Mee, Lee Dae Ho
Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
Chonnam Med J. 2012 Aug;48(2):108-15. doi: 10.4068/cmj.2012.48.2.108. Epub 2012 Aug 24.
The potential relationship between vitamin D (VitD) status and metabolic control in patients with type 2 diabetes mellitus (T2DM) warrants further study. We aimed to evaluate the relationship between the serum 25-hydroxyvitamin D [25(OH)D] level and various parameters in patients with T2DM. We analyzed retrospectively data from 276 Korean patients with T2DM whose serum 25(OH)D level was measured in our hospital. Nondiabetic healthy subjects who visited the hospital for health screening were selected as the control group (Non-DM, n=160). Compared with control subjects, patients with T2DM had a lower serum 25(OH)D level (15.4±0.5 vs. 12.9±0.4 ng/ml, p<0.01). Eleven percent of T2DM patients were VitD "insufficient" (20-29 ng/ml) and 87% of the patients were VitD "deficient" (<20 ng/ml). The serum 25(OH)D level was significantly related to serum fibrinogen, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), ferritin, the urine albumin creatinine ratio, and hemoglobin A(1C) (HbA1C). In a multivariate logistic regression analysis, high levels of HbA1C, TG, and LDL-C were independently associated with VitD deficiency in T2DM patients. The results of the present study show that the majority of Koreans with T2DM are VitD deficient, and the serum 25(OH)D level in patients with T2DM is related to lipid and glucose parameters. Further studies are required of the relationship of VitD with fibrinogen and other related parameters.
2型糖尿病（T2DM）患者的维生素D（VitD）状态与代谢控制之间的潜在关系值得进一步研究。我们旨在评估T2DM患者血清25-羟基维生素D [25(OH)D]水平与各项参数之间的关系。我们回顾性分析了我院测定血清25(OH)D水平的276例韩国T2DM患者的数据。选择因健康筛查来我院就诊的非糖尿病健康受试者作为对照组（非糖尿病组，n = 160）。与对照组相比，T2DM患者的血清25(OH)D水平较低（15.4±0.5 vs. 12.9±0.4 ng/ml，p<0.01）。11%的T2DM患者VitD“不足”（20 - 29 ng/ml），87%的患者VitD“缺乏”（<20 ng/ml）。血清25(OH)D水平与血清纤维蛋白原、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、铁蛋白、尿白蛋白肌酐比值及糖化血红蛋白A1C（HbA1C）显著相关。在多因素逻辑回归分析中，T2DM患者中高水平的HbA1C、TG和LDL-C与VitD缺乏独立相关。本研究结果表明，大多数韩国T2DM患者VitD缺乏，T2DM患者的血清25(OH)D水平与脂质和血糖参数有关。需要进一步研究VitD与纤维蛋白原及其他相关参数之间的关系。
