Sirka Chandra Sekhar
Department of Dermatology and Venereology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Indian J Sex Transm Dis AIDS. 2020 Jul-Dec;41(2):192-195. doi: 10.4103/ijstd.IJSTD_140_15. Epub 2020 Jul 31.
Herpes simplex infection presents as a large, chronic, genital, and perianal ulcer in immunosuppressed HIV-positive patients. However, the characteristic morphological feature for clinical diagnosis is unclear. This case series illustrates the morphological characteristics of large, chronic, herpes simplex ulcers at the genital and perianal region in four HIV-positive patients. The diagnosis of herpes simplex infection was confirmed by laboratory test and/or rapid response to acyclovir therapy. All four of our patients had consistent morphological features such as uniform depth, punched out edge and arcuate border on the genital and perianal ulcers, along with positive IgM and IgG antibodies to herpes simplex virus and/or rapid response to acyclovir. Such findings suggest that these morphological features may be the characteristic feature of large and chronic herpes simplex ulcer in HIV/ADS positive patients.
在免疫抑制的HIV阳性患者中，单纯疱疹感染表现为巨大、慢性的生殖器及肛周溃疡。然而，用于临床诊断的特征性形态学特征尚不清楚。本病例系列阐述了4例HIV阳性患者生殖器及肛周区域巨大、慢性单纯疱疹溃疡的形态学特征。单纯疱疹感染的诊断通过实验室检查和/或对阿昔洛韦治疗的快速反应得以证实。我们所有4例患者的生殖器及肛周溃疡均具有一致的形态学特征，如深度均匀、边缘呈凿孔状及边界呈弓形，同时单纯疱疹病毒IgM和IgG抗体呈阳性和/或对阿昔洛韦反应迅速。这些发现提示，这些形态学特征可能是HIV/AIDS阳性患者巨大、慢性单纯疱疹溃疡的特征性表现。
