评估沙特人群甲状腺对锝-99m 高锝酸盐的摄取的正常参考值。

Assessment of normal reference values for thyroid uptake of technetium-99m pertechnetate in a Saudi population.

机构信息

From the Department of Medicine, National Guard Health Affairs, Riyadh, Saudi Arabia.

From the King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.

出版信息

Ann Saudi Med. 2021 Mar-Apr;41(2):86-90. doi: 10.5144/0256-4947.2021.86. Epub 2021 Apr 1.

DOI:10.5144/0256-4947.2021.86

PMID:33818150

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8020644/

Abstract

BACKGROUND

Thyrotoxicosis is a common medical problem. Thyroid nuclear imaging with either I or technetium-99m (Tc-99m) pertechnetate are used to determine the cause. Although I has been the standard technique, Tc-99m pertechnetate is now commonly used, acceptable and easier to perform. The commonly used normal value of Tc-99m pertechnetate is 1-4%, but lower normal values have been reported in different populations.

OBJECTIVE

Determine normal reference range of Tc-99m pertechne-tate thyroid uptake for thyroid scintigraphy in Saudi Arabia.

DESIGN

Retrospective, cross-sectional.

SETTING

Nuclear medicine service at tertiary care center in Riyadh.

PATIENTS AND METHODS

We used data from biochemically euthyroid patients who underwent a thyroid Tc-99m pertechnetate scan while having parathyroid scintigraphy for hyperparathyroidism between April 2009 to April 2019. Medical records and biochemical thyroid function tests were reviewed and Tc-99m pertechnetate thyroid uptake values were determined for each patient.

MAIN OUTCOME MEASURES

Thyroid uptake of Tc-99m pertechne-tate in euthyroid patients.

SAMPLE SIZE

167 RESULTS: The mean and median uptake of Tc-99m pertechnetate in euthyroid patients were 0.86% and 1.0%, respectively, and the inter-quartile range was 0.0-1.0%. The normal reference range in the study population was 0.2-2%. Thyroid uptake inversely correlated with age in females (r=-0.37, <.001), males (r=-0.46, =.001), and for all patients (r=?0.39, <.0001).

CONCLUSION

The range for normal thyroid Tc-99m pertechnetate was lower than the standard 1-4% range. Moreover, uptake decreased with age. Further studies are needed to establish the normal age-adjusted uptake for the thyroid Tc-99m pertechnetate scan.

LIMITATIONS

Single center and retrospective.

CONFLICT OF INTEREST

None.

摘要

背景

甲状腺功能亢进是一种常见的医学问题。使用碘或锝-99m（Tc-99m）高锝酸盐进行甲状腺核成像，以确定病因。虽然碘一直是标准技术，但 Tc-99m 高锝酸盐现在已被广泛使用，且易于操作，被广泛接受。常用的 Tc-99m 高锝酸盐甲状腺摄取正常值为 1-4%，但在不同人群中已有较低的正常值报道。

目的

确定沙特阿拉伯甲状腺闪烁扫描中 Tc-99m 高锝酸盐甲状腺摄取的正常参考范围。

设计

回顾性、横断面。

地点

利雅得三级保健中心的核医学科。

患者和方法

我们使用了 2009 年 4 月至 2019 年 4 月期间因甲状旁腺功能亢进而接受甲状腺 Tc-99m 高锝酸盐扫描和甲状旁腺闪烁扫描的生化甲状腺功能正常患者的数据。回顾了病历和生化甲状腺功能检查，并确定了每位患者的 Tc-99m 高锝酸盐甲状腺摄取值。

主要观察指标

甲状腺对 Tc-99m 高锝酸盐的摄取在甲状腺功能正常的患者中的表现。

样本量

167 例。

结果

甲状腺功能正常患者的 Tc-99m 高锝酸盐摄取的平均值和中位数分别为 0.86%和 1.0%，四分位间距为 0.0-1.0%。研究人群的正常参考范围为 0.2-2%。女性（r=-0.37，<.001）、男性（r=-0.46，=.001）和所有患者（r=-0.39，<.0001）的甲状腺摄取与年龄呈负相关。