锝摄取的截断值在格雷夫斯病和亚急性甲状腺炎鉴别诊断中的应用
Cut off value of technetium uptake in the differential diagnosis of Graves disease and subacute thyroiditis.
作者信息
Fadime Demir
机构信息
Department of Nuclear Medicine, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey.
出版信息
Asia Ocean J Nucl Med Biol. 2020 Winter;8(1):54-57. doi: 10.22038/aojnmb.2019.14241.
OBJECTIVES
The aim of this study was to determine whether technetium (Tc) uptake is a relevant method for the differential diagnosis of Graves disease and subacute thyroiditis and calculate its cutoff value in case of its relevancy.
METHODS
A total of 69 patients, who were followed up (>3 months) in our hospital for thyrotoxicosis within 2015-2019 were enrolled in the study. Out of these 69 subjects, 39 patients had been diagnosed with Graves disease, and 30 of them had subacute thyroiditis. Biochemical parameters, thyroid scintigraphy, and Tc uptake test results were evaluated.
RESULTS
Tc uptake was significantly higher in the patients with Graves disease than in the patients with subacute thyroiditis (P<0.001). Based on the ROC analysis the Tc uptake cutoff value of 1.55% had an accuracy of 92.9%, with the sensitivity and specificity of 92% and 87%, respectively.
CONCLUSION
In conclusion, the results of our study suggested that Tc uptake test could be used in the differential diagnosis of Graves disease and subacute thyroiditis. The cutoff value of 1.55% for Tc uptake test may guide in establishing a differential diagnosis between the two diseases.
目的
本研究旨在确定锝（Tc）摄取是否为Graves病和亚急性甲状腺炎鉴别诊断的相关方法，并在其具有相关性的情况下计算其临界值。
方法
共有69例在2015 - 2019年期间因甲状腺毒症在我院接受随访（>3个月）的患者纳入本研究。在这69名受试者中，39例患者被诊断为Graves病，30例患有亚急性甲状腺炎。对生化参数、甲状腺闪烁显像和Tc摄取试验结果进行评估。
结果
Graves病患者的Tc摄取显著高于亚急性甲状腺炎患者（P<0.001）。基于ROC分析，Tc摄取临界值为1.55%时，准确率为92.9%，敏感性和特异性分别为92%和87%。
结论
总之，我们的研究结果表明，Tc摄取试验可用于Graves病和亚急性甲状腺炎的鉴别诊断。Tc摄取试验1.55%的临界值可能有助于对这两种疾病进行鉴别诊断。
Zotero 插件