Gholami Amir, Sabbaghi Mahsa, Shirafkan Hoda, Mousavie Anijdan Seyyed Hossein
Department of Nuclear Medicine, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran.
School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Caspian J Intern Med. 2025 Jun 23;16(3):513-518. doi: 10.22088/cjim.16.3.513. eCollection 2025 Summer.
The cause of thyrotoxicosis can be determined through the thyroid uptake of 99mTc-pertechnetate The goal of the study was to calculate the cut-off value of 99mTc-pertechnetate of the thyroid gland for the differential diagnosis of Graves' disease from subacute thyroiditis.
A total of 60 patients were included in the study Based on thyroid scan findings, 30 patients were in the Graves group and 30 of them had been diagnosed as subacute thyroiditis. Biochemical parameters, thyroid scintigraphy, and the percentage thyroidal 99mTc-pertechnetate uptake results were thoroughly assessed.
The mean percentage 99mTc-pertechnetate uptake in Graves group was much higher than that of the subacute thyroiditis group, which was statistically significant (P <0.001). Receiver operating characteristic (ROC) analysis revealed that the uptake cut-off value of 1.1% had the sensitivity and specificity of 97% and 95%, respectively.
The findings depicted that the cutoff value of 1.1% for 99mTc-pertechnetate uptake could be a helpful index to differentiate Graves' disease from subacute thyroiditis, especially when it is difficult to distinguish between the two diseases using conventional diagnostic methods.
甲状腺毒症的病因可通过甲状腺对99m锝-高锝酸盐的摄取来确定。本研究的目的是计算甲状腺99m锝-高锝酸盐摄取的临界值，用于Graves病与亚急性甲状腺炎的鉴别诊断。
本研究共纳入60例患者。根据甲状腺扫描结果，30例患者为Graves组，另外30例被诊断为亚急性甲状腺炎。对生化参数、甲状腺闪烁显像以及甲状腺99m锝-高锝酸盐摄取百分比结果进行了全面评估。
Graves组99m锝-高锝酸盐摄取的平均百分比远高于亚急性甲状腺炎组，差异具有统计学意义（P<0.001）。受试者工作特征（ROC）分析显示，摄取临界值为1.1%时，敏感性和特异性分别为97%和95%。
研究结果表明，99m锝-高锝酸盐摄取的临界值为1.1%可能是区分Graves病与亚急性甲状腺炎的有用指标，尤其是在使用传统诊断方法难以区分这两种疾病时。
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