Frye Brett M, Craft Suzanne, Register Thomas C, Kim Jeongchul, Whitlow Christopher T, Barcus Richard A, Lockhart Samuel N, Sai Kiran Kumar Solingapuram, Shively Carol A
Department of Pathology/Comparative Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA.
Department of Internal Medicine/Gerontology Wake Forest School of Medicine Winston-Salem North Carolina USA.
Alzheimers Dement (N Y). 2022 Mar 13;8(1):e12284. doi: 10.1002/trc2.12284. eCollection 2022.
Age-related neuropathology associated with sporadic Alzheimer's disease (AD) often develops well before the onset of symptoms. Given AD's long preclinical period, translational models are needed to identify early signatures of pathological decline.
Using structural magnetic resonance imaging and cognitive assessments, we examined the relationships among age, cognitive performance, and neuroanatomy in 48 vervet monkeys () ranging from young adults to very old.
We found negative associations of age with cortical gray matter volume ( = .003) and the temporal-parietal cortical thickness meta-region of interest ( = .001). Additionally, cortical gray matter volumes predicted working memory at approximately 1-year follow-up (correct trials at the 20s delay [ = .008]; correct responses after longer delays [ = .004]).
Cortical gray matter diminishes with age in vervets in regions relevant to AD, which may increase risk of cognitive impairment. This study lays the groundwork for future investigations to test therapeutics to delay or slow pathological decline.
与散发性阿尔茨海默病（AD）相关的年龄相关性神经病理学通常在症状出现之前很久就已发展。鉴于AD的漫长临床前期，需要转化模型来识别病理衰退的早期特征。
我们使用结构磁共振成像和认知评估，研究了48只从青年到非常老年的黑长尾猴的年龄、认知表现和神经解剖结构之间的关系。
我们发现年龄与皮质灰质体积呈负相关（P = 0.003），与颞顶叶皮质厚度感兴趣元区域呈负相关（P = 0.001）。此外，皮质灰质体积在大约1年的随访中预测工作记忆（20秒延迟时的正确试验次数[P = 0.008]；更长延迟后的正确反应次数[P = 0.004]）。
在与AD相关的区域，黑长尾猴的皮质灰质随年龄减少，这可能增加认知障碍的风险。本研究为未来测试延缓或减缓病理衰退的疗法的研究奠定了基础。
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