Department of Dermatology, Medical College of Georgia, Augusta University Medical Center, Augusta, GA.
Dermatol Online J. 2021 Feb 15;27(2):13030/qt51h201bj.
Loose anagen syndrome (LAS) is a hair disorder involving insufficient anchoring of the hair follicle to the scalp owing to an autosomal dominant or sporadic mutation in the gene encoding keratin 6. There are three phenotypes of LAS, including type B, which presents in young, light-haired girls as unruly, uncombable hair with diminished growth. We present a 2-year-old girl with LAS type B whose identical twin sister was unaffected. The diagnosis was confirmed with a painless hair pull test proven to contain anagen hairs with ruffled cuticles on trichoscopy, preventing the need for unnecessary referrals and diagnostic tests.
休止期脱发综合征（LAS）是一种毛发疾病，由于编码角蛋白 6 的基因发生常染色体显性或散发性突变，导致毛囊与头皮的锚固不足。LAS 有三种表型，包括 B 型，其特征是年轻的浅色头发女孩出现不羁、不可梳理的头发，生长减少。我们介绍了一位 2 岁的 LAS 型 B 患者，其同卵双胞胎姐姐未受影响。通过无痛性毛发牵拉试验证实存在生长期毛发，毛发镜下毛干卷曲、角化细胞紊乱，诊断得以明确，从而避免了不必要的转诊和诊断性检查。
