Schulz S C, Cornelius J, Schulz P M, Soloff P H
Schizophrenia Research Branch, National Institute of Mental Health, Rockville, MD 20857.
Am J Psychiatry. 1988 Jul;145(7):809-14. doi: 10.1176/ajp.145.7.809.
The authors used amphetamine as a psychopharmacological probe to investigate the hypothesis that patients with borderline personality disorder are prone to psychosis following ingestion of a dopamine agonist. Sixteen patients with borderline personality disorder participated in the study. Significant increases in the mean total Brief Psychiatric Rating Scale scores and in activation and thought disturbance factors after amphetamine administration were noted in the sample. Patients with diagnoses of both schizotypal and borderline personality disorders worsened transiently with amphetamine administration, but patients with only the borderline diagnosis improved. These results indicate the usefulness of pharmacological probes to further understand DSM-III axis II disorders.
作者使用苯丙胺作为一种精神药理学探针，以研究边缘型人格障碍患者在摄入多巴胺激动剂后易患精神病这一假说。16名边缘型人格障碍患者参与了该研究。研究样本中，服用苯丙胺后，简明精神病评定量表平均总分以及激活和思维障碍因子均显著增加。同时患有分裂型人格障碍和边缘型人格障碍的患者在服用苯丙胺后病情短暂恶化，但仅患有边缘型人格障碍的患者病情有所改善。这些结果表明，药理学探针有助于进一步了解《精神疾病诊断与统计手册》第三版轴II障碍。
