肺癌中癌相关成纤维细胞衍生外泌体的研究进展
[Advancement of Cancer Associated Fibroblasts-derived Exosomes in Lung Cancer].
作者信息
Shen Cheng, Li Jue, Li Jialong, Che Guowei
机构信息
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2021 Mar 20;24(3):212-216. doi: 10.3779/j.issn.1009-3419.2021.102.07.
Abstract
Tumor microenvironment (TME) is a dynamic network distributed around tumor cells. Cancer-associated fibroblasts (CAFs), as an important component of the TME, are not only closely related to normal fibroblasts, but also can secrete a variety of substances to participate in the regulation of the TME. Exosomes, one of the substances from CAFs, can promote the formation and development of lung cancer, including promoting the formation of TME, increasing pulmonary tumor cell invasion and metastasis, mediating pulmonary tumor immunosuppression and participating in radiotherapy and chemotherapy resistance. This article reviews the current research status and progress of cancer associated fibroblasts-derived exosomes in lung cancer. .
摘要
肿瘤微环境（TME）是围绕肿瘤细胞分布的动态网络。癌症相关成纤维细胞（CAFs）作为TME的重要组成部分，不仅与正常成纤维细胞密切相关，还能分泌多种物质参与TME的调节。外泌体是CAFs分泌的物质之一，可促进肺癌的形成和发展，包括促进TME的形成、增加肺肿瘤细胞的侵袭和转移、介导肺肿瘤免疫抑制以及参与放化疗耐药。本文综述了癌症相关成纤维细胞来源的外泌体在肺癌中的研究现状和进展。
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