Ting S, Rauls D O, Ashbaugh P, Mansfield L E
Department of Medicine, Allergy and Immunology Service, William Beaumont Army Medical Center, El Paso, Texas.
Ann Allergy. 1988 Jun;60(6):527-30.
Urticaria, after ingesting ethanol, is rare. A 36-year-old Caucasian male developed multiple, generalized, pruritic urticarial lesions 5 to 15 minutes after drinking alcoholic beverages of any type. A blinded challenge with 5 mL of chemically pure 95% ethanol in concentrated grape juice caused urticaria and an elevation of plasma histamine. Pure grape juice alone was unreactive. Prick skin tests with Brewers' yeast, ethanol, acetaldehyde, and acetic acid were negative. Hydroxyzine (25 mg, p.o., q.i.d.), given for three days prior to challenge, inhibited skin response and histamine release. Biopsy of the urticarial lesions caused by ethanol ingestion showed mast cell degranulation. In this subject, ethanol appeared to directly affect mast cell mediator release by non-IgE mechanisms.
饮酒后发生荨麻疹的情况较为罕见。一名36岁的白种男性在饮用任何类型的酒精饮料后5至15分钟，出现了多发的、全身性的、瘙痒性荨麻疹皮损。用5毫升化学纯的95%乙醇加浓缩葡萄汁进行双盲激发试验引发了荨麻疹，并导致血浆组胺升高。单独使用纯葡萄汁则无反应。用啤酒酵母、乙醇、乙醛和乙酸进行的皮肤点刺试验均为阴性。在激发试验前三天给予羟嗪（25毫克，口服，每日四次）抑制了皮肤反应和组胺释放。乙醇摄入引起的荨麻疹皮损活检显示肥大细胞脱颗粒。在该患者中，乙醇似乎通过非IgE机制直接影响肥大细胞介质的释放。
