Okuda M, Watase T, Mezawa A, Liu C M
Nippon Medical School, Department of Otorhinolaryngology, Tokyo, Japan.
Ann Allergy. 1988 Jun;60(6):537-40.
We investigated the clinical significance of leukotriene D4 (LTD4) in nasal symptoms of allergy and compared this with antigen and histamine. Nasal provocations were carried out in patients with allergic rhinitis using serially increasing doses of LTD4, histamine, or antigen. The nasal responses induced were evaluated by counting the number of sneezes, the quantity of nasal secretion, and of nasal airway resistance. When the effects of topical provoking agents were compared at the threshold concentration, LTD4 produced no sneezing--unlike antigen and histamine--increased nasal secretion to a lesser degree than antigen and histamine (P less than .001), and increased nasal airway resistance similar to histamine but less than antigen (P less than .1) and longer than histamine, and similar to antigen in duration. LTD4 was approximately 5,000 times stronger than histamine in threshold concentration for nasal response. In conclusion, LTD4 plays an important role in nasal allergy presumably through long lasting and strong nasal blockage effects.
我们研究了白三烯D4（LTD4）在变应性鼻症状中的临床意义，并将其与抗原和组胺进行比较。使用剂量递增的LTD4、组胺或抗原对变应性鼻炎患者进行鼻激发试验。通过计数喷嚏次数、鼻分泌物量和鼻气道阻力来评估诱发的鼻反应。当在阈浓度比较局部激发剂的作用时，LTD4不引起喷嚏，与抗原和组胺不同；增加鼻分泌物的程度低于抗原和组胺（P＜0.001）；增加鼻气道阻力的情况与组胺相似但低于抗原（P＜0.1），且持续时间比组胺长，与抗原相似。LTD4在引起鼻反应的阈浓度方面比组胺强约5000倍。总之，LTD4可能通过持久且强烈的鼻阻塞作用在鼻变应性疾病中起重要作用。
