Mion Olavo de Godoy, Mello João Ferreira de, Dutra Daniel Lorena, Andrade Nilvano Alves de, Almeida Washington Luiz de Cerqueira, Anselmo-Lima Wilma Teresinha, Filho Leonardo Lopes Balsalobre, Carvalho E Castro Jair de, Guimarães Roberto Eustáquio Dos Santos, Lessa Marcus Miranda, Maniglia Sérgio Fabrício, Meireles Roberto Campos, Nakanishi Márcio, Pignatari Shirley Shizue Nagata, Roithmann Renato, Romano Fabrizio Ricci, Santos Rodrigo de Paula, Santos Marco César Jorge Dos, Tamashiro Edwin
Universidade de São Paulo (USP), Disciplina de Otorrinolaringologia, São Paulo, SP, Brazil.
Universidade de São Paulo (USP), Faculdade de Medicina, São Paulo, SP, Brazil.
Braz J Otorhinolaryngol. 2017 Mar-Apr;83(2):215-227. doi: 10.1016/j.bjorl.2017.01.002. Epub 2017 Jan 21.
Inflammatory conditions of the nose and paranasal sinuses are very prevalent in the general population, resulting in marked loss of quality of life in affected patients, as well as significant work, leisure, and social activity losses. These patients require specific and specialized treatment. A wide range of oral medications are available.
The present document is aimed to clarify, for professionals treating patients with inflammatory sinonasal diseases, both specialists and general practitioners, specific oral therapies in noninfectious nasal inflammatory conditions.
The methodology used to create this article included the search for the key words: oral corticosteroids, antihistamines, antileukotrienes, rhinitis, rhinosinusitis in the MEDLINE and EMBASE databases in the last 5 years. Since no relevant article was found for the text on the subject of interest in the last 5 years, the search was extended for another 5 years, and so on, according to the authors' needs.
Relevant literature was found regarding the use of antihistamines, antileukotrienes and oral corticosteroids in these conditions. The Brazilian Academy of Rhinology emphasizes, after extensive discussion by the collegiate, key points in the treatment with these drugs.
There is support in the literature for the use of these drugs; however, final considerations about the role of each of them have been made.
鼻和鼻窦的炎性疾病在普通人群中非常普遍，导致受影响患者的生活质量显著下降，以及工作、休闲和社交活动的大量损失。这些患者需要特定的专业治疗。有多种口服药物可供使用。
本文旨在为治疗炎性鼻窦疾病患者的专业人员（包括专科医生和全科医生）阐明非感染性鼻炎性疾病的特定口服疗法。
撰写本文所使用的方法包括在过去5年的MEDLINE和EMBASE数据库中搜索关键词：口服糖皮质激素、抗组胺药、白三烯调节剂、鼻炎、鼻窦炎。由于在过去5年中未找到关于该主题文本的相关文章，根据作者的需要，搜索范围又延长了5年，依此类推。
发现了关于在这些疾病中使用抗组胺药、白三烯调节剂和口服糖皮质激素的相关文献。巴西鼻科学会在委员会进行广泛讨论后，强调了这些药物治疗的要点。
文献支持使用这些药物；然而，已经对它们各自的作用进行了最终考量。
