Institute for Virology and Immunobiology, University of Würzburg, 97070 Würzburg, Germany; and
Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55122 Mainz, Germany.
J Immunol. 2021 Apr 15;206(8):1681-1689. doi: 10.4049/jimmunol.2001315.
The original concept stated that immature dendritic cells (DC) act tolerogenically whereas mature DC behave strictly immunogenically. Meanwhile, it is also accepted that phenotypically mature stages of all conventional DC subsets can promote tolerance as steady-state migratory DC by transporting self-antigens to lymph nodes to exert unique functions on regulatory T cells. We propose that in vivo 1) there is little evidence for a tolerogenic function of immature DC during steady state such as CD4 T cell anergy induction, 2) all tolerance as steady-state migratory DC undergo common as well as subset-specific molecular changes, and 3) these changes differ by quantitative and qualitative markers from immunogenic DC, which allows one to clearly distinguish tolerogenic from immunogenic migratory DC.
最初的概念表明，未成熟树突状细胞（DC）表现出耐受性，而成熟的 DC 则表现出严格的免疫原性。同时，人们也接受这样一种观点，即所有常规 DC 亚群的表型成熟阶段都可以通过将自身抗原运送到淋巴结来作为稳态迁移 DC 发挥独特的功能，从而促进耐受性，作用于调节性 T 细胞。我们提出，在体内：1）稳态时未成熟 DC 几乎没有表现出耐受性的功能，例如 CD4 T 细胞失能诱导；2）所有作为稳态迁移 DC 的耐受作用都经历共同的以及亚群特异性的分子变化；3）这些变化与免疫原性 DC 的数量和质量标记物不同，这使得人们能够清楚地区分耐受性和免疫原性迁移 DC。
