Sala Valentina, Della Sala Angela, Ghigo Alessandra, Hirsch Emilio
Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Torino, Italy.
Kither Biotech S.r.l. Via Nizza 52, 10126, Torino, Italy.
Cell Stress. 2021 Mar 8;5(4):40-51. doi: 10.15698/cst2021.04.246.
Phosphatidyl inositol 3 kinase gamma (PI3Kγ) is expressed in all the cell types that are involved in airway inflammation and disease, including not only leukocytes, but also structural cells, where it is expressed at very low levels under physiological conditions, while is significantly upregulated after stress. In the airways, PI3Kγ behaves as a trigger or a controller, depending on the pathological context. In this review, the contribution of PI3Kγ in a plethora of respiratory diseases, spanning from acute lung injury, pulmonary fibrosis, asthma, cystic fibrosis and response to both bacterial and viral pathogens, will be commented.
磷脂酰肌醇3激酶γ（PI3Kγ）在所有参与气道炎症和疾病的细胞类型中均有表达，这些细胞类型不仅包括白细胞，还包括结构细胞，在生理条件下PI3Kγ在结构细胞中表达水平非常低，而在应激后会显著上调。在气道中，根据病理背景，PI3Kγ既可以作为触发因子，也可以作为调控因子。在本综述中，将对PI3Kγ在多种呼吸系统疾病中的作用进行阐述，这些疾病包括急性肺损伤、肺纤维化、哮喘、囊性纤维化以及对细菌和病毒病原体的反应。
