Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Laboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland.
World J Biol Psychiatry. 2021 Dec;22(10):744-756. doi: 10.1080/15622975.2021.1907715. Epub 2021 Apr 27.
A significant challenge in psychiatry is the differential diagnosis of depressive episodes in the course of mood disorders. Gene expression profiling may provide an opportunity for such distinguishment.
We studied differentially expressed genes in women with a depressive episode in the course of unipolar depression (UD) ( = 24) and bipolar disorder types I (BDI) ( = 13) and II (BDII) ( = 19), and healthy controls ( = 15).
Different types of depression varied in the number and type of up or down-regulated genes. The pathway analysis showed: in UD, up-regulated rheumatoid arthritis pathway (including genes), and down-regulated taste transduction pathway (); in BDI, eight down-regulated pathways: glutamatergic synapse, retrograde endocannabinoid signalling, axon guidance, calcium signalling, nicotine addiction, PI3K-Akt signalling, drug metabolism - cytochrome P450, and morphine addiction; in BDII, up-regulated osteoclast differentiation and Notch signalling pathway, and down-regulated type I diabetes mellitus pathway. Distinct expression markers analysis uncovered the unique for UD, up-regulated bladder cancer pathway ( and ).
This pilot study suggests a probability of differentiating depression in the course of UD, BDI, and II, based on transcriptomic profiling.
在精神病学中，一个重大的挑战是在心境障碍的病程中对抑郁发作进行鉴别诊断。基因表达谱分析可能为此提供了机会。
我们研究了单相抑郁（UD）（n=24）、双相 I 型障碍（BDI）（n=13）和 II 型障碍（BDII）（n=19）女性在抑郁发作期间以及健康对照组（n=15）中差异表达的基因。
不同类型的抑郁症在上调或下调基因的数量和类型上存在差异。通路分析显示：在 UD 中，上调的类风湿关节炎通路（包括 个基因）和下调的味觉转导通路（）；在 BDI 中，八个下调的通路：谷氨酸能突触、逆行内源性大麻素信号转导、轴突导向、钙信号转导、尼古丁成瘾、PI3K-Akt 信号转导、药物代谢-细胞色素 P450 和吗啡成瘾；在 BDII 中，上调破骨细胞分化和 Notch 信号通路，下调 I 型糖尿病通路。独特表达标志物分析揭示了 UD 的独特上调的膀胱癌通路（和）。
这项初步研究表明，基于转录组谱分析，有可能区分 UD、BDI 和 II 中的抑郁症。
