类风湿关节炎中与硫唑嘌呤相关的全血细胞减少症。
Pancytopenia related to azathioprine in rheumatoid arthritis.
作者信息
Jeurissen M E, Boerbooms A M, van de Putte L B
机构信息
Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
出版信息
Ann Rheum Dis. 1988 Jun;47(6):503-5. doi: 10.1136/ard.47.6.503.
Abstract
Two patients with rheumatoid arthritis developed pancytopenia during treatment with azathioprine 100 mg daily. In one patient this side effect occurred after three weeks, in the other after eight weeks of treatment. Rapid fall of platelets in one patient necessitated platelet transfusion. In the other patient additional treatment with allopurinol was probably responsible for the toxic effect. Haematological side effects of azathioprine are discussed.
摘要
两名类风湿性关节炎患者在每日服用100毫克硫唑嘌呤治疗期间出现全血细胞减少。其中一名患者在治疗三周后出现这种副作用，另一名患者在治疗八周后出现。一名患者血小板迅速下降，需要进行血小板输注。另一名患者加用别嘌醇治疗可能是导致毒性作用的原因。本文讨论了硫唑嘌呤的血液学副作用。
相似文献
1
Pancytopenia related to azathioprine in rheumatoid arthritis.类风湿关节炎中与硫唑嘌呤相关的全血细胞减少症。
Ann Rheum Dis. 1988 Jun;47(6):503-5. doi: 10.1136/ard.47.6.503.
2
Rapidly evolving azathioprine induced pancytopenia.
J Rheumatol. 1987 Aug;14(4):862.
3
Pancytopenia in systemic lupus erythematosus related to azathioprine.系统性红斑狼疮中与硫唑嘌呤相关的全血细胞减少症。
J Intern Med. 1990 Jan;227(1):69-72. doi: 10.1111/j.1365-2796.1990.tb00121.x.
4
Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis.一名青少年HLA-B27相关脊柱关节炎患者因硫嘌呤甲基转移酶基因纯合双点突变导致硫唑嘌呤诱发的严重全血细胞减少症。
Arthritis Rheum. 1997 Oct;40(10):1896-8. doi: 10.1002/art.1780401026.
5
The oncogenicity of chlorambucil in rheumatoid arthritis.
Br J Rheumatol. 1988 Feb;27(1):44-7. doi: 10.1093/rheumatology/27.1.44.
6
Azathioprine-induced pancytopenia. Occurrence in two patients with connective-tissue diseases.硫唑嘌呤诱发的全血细胞减少症。两名结缔组织病患者的病例报告
Arch Intern Med. 1981 Feb;141(2):223-6.
7
8
Azathioprine and penicillamine in treatment of rheumatoid arthritis: a controlled trial.硫唑嘌呤和青霉胺治疗类风湿关节炎的对照试验。
Br Med J. 1976 May 1;1(6017):1052-4. doi: 10.1136/bmj.1.6017.1052.
9
[Azathioprine-associated severe myelosuppression: indication of routine determination of thiopurine S-methyltransferase variant?].[硫唑嘌呤相关的严重骨髓抑制：常规检测硫嘌呤S-甲基转移酶变异体的指征？]
Rev Med Interne. 2011 Jun;32(6):373-6. doi: 10.1016/j.revmed.2010.09.006. Epub 2010 Oct 20.
10
Ulcerative colitis: prolonged remission following azathioprine-induced pancytopenia.
J Clin Gastroenterol. 1989 Jun;11(3):327-30.
引用本文的文献
1
High discontinuation rate of azathioprine in autoimmune hepatitis, independent of time of treatment initiation.自身免疫性肝炎中硫唑嘌呤停药率高，与治疗开始时间无关。
Liver Int. 2020 Sep;40(9):2164-2171. doi: 10.1111/liv.14513. Epub 2020 Jun 11.
2
Modeling the Outcome of Systematic TPMT Genotyping or Phenotyping Before Azathioprine Prescription: A Cost-Effectiveness Analysis.在开阿扎胞苷前进行系统 TPMT 基因分型或表型分析的结果建模：成本效益分析。
Mol Diagn Ther. 2019 Jun;23(3):429-438. doi: 10.1007/s40291-019-00398-x.
3
Association of thiopurine methyltransferase status with azathioprine side effects in Chinese patients with systemic lupus erythematosus.硫嘌呤甲基转移酶状态与中国系统性红斑狼疮患者硫唑嘌呤副作用的相关性
Clin Rheumatol. 2014 Apr;33(4):499-503. doi: 10.1007/s10067-013-2441-x. Epub 2013 Dec 10.
4
Monitoring of nonsteroidal immunosuppressive drugs in patients with lung disease and lung transplant recipients: American College of Chest Physicians evidence-based clinical practice guidelines.监测肺疾病和肺移植受者的非甾体免疫抑制剂：美国胸科医师学会循证临床实践指南。
Chest. 2012 Nov;142(5):e1S-e111S. doi: 10.1378/chest.12-1044.
5
The haemotoxicity of azathioprine in repeat dose studies in the female CD-1 mouse.硫唑嘌呤在雌性CD-1小鼠重复给药研究中的血液毒性。
Int J Exp Pathol. 2008 Apr;89(2):138-58. doi: 10.1111/j.1365-2613.2008.00575.x.
6
Purine enzyme activities in recent onset rheumatoid arthritis: are there differences between patients and healthy controls?近期发病类风湿关节炎中的嘌呤酶活性：患者与健康对照之间是否存在差异？
Ann Rheum Dis. 1996 Oct;55(10):733-8. doi: 10.1136/ard.55.10.733.
7
Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.硫唑嘌呤所致炎症性肠病的骨髓毒性：27年经验总结
Gut. 1993 Aug;34(8):1081-5. doi: 10.1136/gut.34.8.1081.
8
The role of erythropoietin in the anaemia of chronic disease in rheumatoid arthritis.
Clin Rheumatol. 1990 Mar;9(1):22-7. doi: 10.1007/BF02030236.
9
Anaemia in rheumatoid arthritis: pathogenesis, diagnosis and treatment.类风湿关节炎中的贫血：发病机制、诊断与治疗
Rheumatol Int. 1990;9(6):243-57. doi: 10.1007/BF00541320.
10
Pancytopenia related to azathioprine--an enzyme deficiency caused by a common genetic polymorphism: a review.与硫唑嘌呤相关的全血细胞减少症——一种由常见基因多态性引起的酶缺乏症：综述
J R Soc Med. 1992 Dec;85(12):752-6. doi: 10.1177/014107689208501213.
本文引用的文献
1
[Myelosuppression with macrocytic anaemia and leucopenia during treatment with azathioprine in myasthenia gravis].
Dtsch Med Wochenschr. 1982 Oct 22;107(42):1592-4. doi: 10.1055/s-2008-1070172.
2
Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities.类风湿性关节炎：硫唑嘌呤（依木兰）治疗。临床副作用及实验室异常情况。
Ann Rheum Dis. 1982;41 Suppl 1(Suppl 1):44-7. doi: 10.1136/ard.41.suppl_1.44.
3
[Pancytopenia following combination treatment with allopurinol and azathioprine].[别嘌醇与硫唑嘌呤联合治疗后出现的全血细胞减少症]
Med Welt. 1976 Aug 13;27(33):1545-6.
4
Azathioprine-induced pure red blood cell aplasia.
JAMA. 1978 Aug 11;240(6):552-4.
Zotero 插件