Jeurissen M E, Boerbooms A M, van de Putte L B
Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
Ann Rheum Dis. 1988 Jun;47(6):503-5. doi: 10.1136/ard.47.6.503.
Two patients with rheumatoid arthritis developed pancytopenia during treatment with azathioprine 100 mg daily. In one patient this side effect occurred after three weeks, in the other after eight weeks of treatment. Rapid fall of platelets in one patient necessitated platelet transfusion. In the other patient additional treatment with allopurinol was probably responsible for the toxic effect. Haematological side effects of azathioprine are discussed.
两名类风湿性关节炎患者在每日服用100毫克硫唑嘌呤治疗期间出现全血细胞减少。其中一名患者在治疗三周后出现这种副作用，另一名患者在治疗八周后出现。一名患者血小板迅速下降，需要进行血小板输注。另一名患者加用别嘌醇治疗可能是导致毒性作用的原因。本文讨论了硫唑嘌呤的血液学副作用。
