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在 COVID-19 大流行期间,访问埃塞俄比亚公立卫生机构的糖尿病和高血压患者药物治疗依从性差的程度及其相关因素。

Magnitude and associated factors of poor medication adherence among diabetic and hypertensive patients visiting public health facilities in Ethiopia during the COVID-19 pandemic.

机构信息

Research Directorate, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Department of Neurology, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

出版信息

PLoS One. 2021 Apr 6;16(4):e0249222. doi: 10.1371/journal.pone.0249222. eCollection 2021.

Abstract

OBJECTIVE

This study aims to assess the magnitude and associated factors of poor medication adherence among diabetic and hypertensive patients visiting public health facilities in Addis Ababa, Ethiopia during the COVID-19 pandemic.

METHODS

A multi-site cross-sectional design was conducted from 1st through 30th of August 2020 at public health facilities of the study area. Adult outpatients with T2DM and hypertension visiting hospitals and health centers were included in the study. A proportion to size allocation method was used to determine the required sample size per facility. Data was collected using the 8-item Morisky medication adherence scale. Descriptive statistics and binary logistic regression were used to analyze data. A 95% confidence interval and p≤0.05 statistical significance was considered to determine factors associated with poor medication adherence.

RESULTS

A total of 409 patients were included in the present study. About 57% of the patients reported that the COVID-19 pandemic has posed negative impacts on either of their follow-up visits, availability of medications, or affordability of prices. And, 21% have reported that they have been affected in all aspects. The overall magnitude of poor medication adherence was 72%. Patients with extreme poverty were more likely to have good medication adherence (AOR: 0.59; 95%C.I: 0.36-0.97), whereas attendance to a health center (AOR: 1.71; 95%C.I: 1.02-2.85), presence of comorbidity (AOR: 2.05; 95%C.I: 1.13-3.71), and current substance use history (AOR: 11.57; 95%C.I: 1.52-88.05) predicted high odds of poor adherence.

CONCLUSION

Over a three-fourth of the patients, in the study setting, have poor adherence to their anti-diabetic and antihypertensive medications. Health facility type, income level, comorbidity, and current substance use history showed a statistically significant association with poor adherence to medication. Stakeholders should set alternative strategies as perceived impacts of the COVID-19 pandemic on medication adherence are high in the study area.

摘要

目的

本研究旨在评估在 COVID-19 大流行期间,埃塞俄比亚亚的斯亚贝巴公立卫生机构就诊的糖尿病和高血压患者药物治疗依从性不佳的程度及其相关因素。

方法

2020 年 8 月 1 日至 30 日,在研究地区的公立卫生机构进行了多地点横断面设计。本研究纳入了前往医院和卫生中心就诊的 2 型糖尿病和高血压的成年门诊患者。采用比例分配方法确定每个医疗机构所需的样本量。使用 8 项 Morisky 药物治疗依从性量表收集数据。采用描述性统计和二元逻辑回归分析数据。采用 95%置信区间和 p≤0.05 的统计学意义来确定与药物治疗依从性不佳相关的因素。

结果

本研究共纳入了 409 名患者。约 57%的患者报告 COVID-19 大流行对他们的随访、药物供应或药物价格可负担性产生了负面影响。其中 21%的患者报告说他们在所有方面都受到了影响。药物治疗依从性不佳的总体程度为 72%。极度贫困的患者更有可能有良好的药物治疗依从性(AOR:0.59;95%CI:0.36-0.97),而就诊于卫生中心(AOR:1.71;95%CI:1.02-2.85)、合并症存在(AOR:2.05;95%CI:1.13-3.71)和当前物质使用史(AOR:11.57;95%CI:1.52-88.05)与较差的药物治疗依从性相关。

结论

在研究环境中,超过四分之三的患者对其抗糖尿病和抗高血压药物的依从性较差。医疗机构类型、收入水平、合并症和当前物质使用史与药物治疗依从性差有统计学显著关联。利益相关者应制定替代策略,因为 COVID-19 大流行对该研究地区药物治疗依从性的影响是巨大的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c609/8023457/09456c7b7057/pone.0249222.g001.jpg

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