在 COVID-19 大流行期间,埃塞俄比亚东部吉吉加市公立医院的抗逆转录病毒治疗依从性及其相关因素:一项横断面研究。

Level of antiretroviral therapy adherence and associated factors during COVID-19 pandemic era in public hospitals of Jigjiga City eastern Ethiopia: a cross-sectional study.

机构信息

Jigjiga Regional Health Bureau, Jigjiga, Ethiopia.

School of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

出版信息

Front Public Health. 2024 May 24;12:1363903. doi: 10.3389/fpubh.2024.1363903. eCollection 2024.

Abstract

BACKGROUND

Coronavirus-19 disease is more severe in patients on antiretroviral therapy (ART). Low-income countries, such as those in Sub-Saharan Africa, are particularly vulnerable to the virus' spread. However, there is little information on antiretroviral therapy (ART) use in Ethiopia during the pandemic, particularly in the study area. Therefore, this study aimed to assess the level of antiretroviral treatment adherence and associated factors during the COVID-19 pandemic era in public hospitals in Jigjiga City, Somalia, and Eastern Ethiopia.

METHODS

An institution-based cross-sectional study was conducted among 382 randomly selected HIV patients on antiretroviral therapy (ART) follow-up in public hospitals in Jigjiga City from March 1-30, 2022. The data was collected through face-to-face interviews and a review of the patient's record. To explore the relationship between variables, both bivariate and multivariable logistic regression analyses were performed. The adjusted odds ratio (AOR) was utilized, along with a 95% confidence interval, to assess the strength and direction of the association. Statistical significance was considered at  < 0.05.

RESULTS

The antiretroviral therapy (ART) adherence rate of HIV patients was 76.9% (95% CI, 71.9-82). Disclosing HIV status to sexual partners [AOR = 2.3, (95% CI (1.22-4.19)], having communication with health care providers' [AOR = 3.2, (95% CI (1.57-6.53)], having no history of current substance use [AOR = 2.6, (95% CI (1.45-4.63)], and patients who did not fear COVID-19 infection [AOR = 5.8 (95% CI (11-10.98)] were significantly associated with antiretroviral therapy (ART) adherence.

CONCLUSION

In this study, the level of antiretroviral therapy (ART) adherence was poor in comparison to the expected level. Patients' adherence status was favorably related to disclosing their status to families and having contact with their healthcare providers, whereas worrying about COVID-19 pandemic infection and current substance use was adversely associated.

摘要

背景

冠状病毒-19 疾病在接受抗逆转录病毒治疗(ART)的患者中更为严重。像撒哈拉以南非洲这样的低收入国家特别容易受到该病毒的传播。然而,在大流行期间,关于埃塞俄比亚的抗逆转录病毒治疗(ART)使用情况,特别是在研究地区,几乎没有信息。因此,本研究旨在评估在索马里的吉吉加市和埃塞俄比亚东部的公立医院中,在 COVID-19 大流行期间接受抗逆转录病毒治疗(ART)的患者的抗逆转录病毒治疗依从水平及其相关因素。

方法

这是一项在 2022 年 3 月 1 日至 30 日期间在吉吉加市公立医院接受抗逆转录病毒治疗(ART)随访的 382 名随机选择的 HIV 患者中进行的机构间横断面研究。通过面对面访谈和查阅患者记录收集数据。为了探索变量之间的关系,进行了单变量和多变量逻辑回归分析。使用调整后的优势比(AOR)以及 95%置信区间来评估关联的强度和方向。统计显著性定义为  < 0.05。

结果

艾滋病毒患者的抗逆转录病毒治疗(ART)依从率为 76.9%(95%CI,71.9-82)。向性伴侣透露 HIV 状况 [AOR=2.3,(95%CI(1.22-4.19)]、与医疗保健提供者进行沟通 [AOR=3.2,(95%CI(1.57-6.53)]、没有当前物质使用史 [AOR=2.6,(95%CI(1.45-4.63)]以及不担心 COVID-19 感染 [AOR=5.8(95%CI(11-10.98)]与抗逆转录病毒治疗(ART)依从性显著相关。

结论

在这项研究中,抗逆转录病毒治疗(ART)的依从水平与预期水平相比较差。患者的依从状况与向家人透露自己的状况以及与医疗保健提供者接触有关,而担心 COVID-19 大流行感染和当前物质使用则与之相反。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6775/11156993/4b9bb4d18752/fpubh-12-1363903-g001.jpg

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