KU Leuven, Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, Leuven, Belgium; KU Leuven Brain Institute (LBI), Leuven, Belgium.
KU Leuven, Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, Leuven, Belgium; KU Leuven Brain Institute (LBI), Leuven, Belgium.
Neuroscience. 2021 Jun 15;465:203-218. doi: 10.1016/j.neuroscience.2021.03.027. Epub 2021 Apr 3.
Previous research has shown that targeted memory reactivation (TMR) protocols using acoustic or olfactory stimuli can boost motor memory consolidation. While somatosensory information is crucial for motor control and learning, the effects of somatosensory TMR on motor memory consolidation remain elusive. Here, healthy young adults (n = 28) were trained on a sequential serial reaction time task and received, during the offline consolidation period that followed, sequential electrical stimulation of the fingers involved in the task. This somatosensory TMR procedure was applied during either a 90-minute diurnal sleep (NAP) or wake (NONAP) interval that was monitored with electroencephalography. Consolidation was assessed with a retest following the NAP/NONAP episode. Behavioral results revealed no effect of TMR on motor performance in either of the groups. At the brain level, somatosensory stimulation elicited changes in oscillatory activity in both groups. Specifically, TMR induced an increase in power in the mu band in the NONAP group and in the beta band in both the NAP and NONAP groups. Additionally, TMR elicited an increase in sigma power and a decrease in delta oscillations in the NAP group. None of these TMR-induced modulations of oscillatory activity, however, were correlated with measures of motor memory consolidation. The present results collectively suggest that while somatosensory TMR modulates oscillatory brain activity during post-learning sleep and wakefulness, it does not influence motor performance in an immediate retest.
先前的研究表明，使用声或嗅刺激的靶向记忆再激活（TMR）方案可以促进运动记忆巩固。虽然体感信息对于运动控制和学习至关重要，但体感 TMR 对运动记忆巩固的影响仍不清楚。在这里，健康的年轻成年人（n=28）接受了一项序列连续反应时间任务的训练，并在随后的离线巩固期间接受了参与任务的手指的顺序电刺激。这种体感 TMR 程序在监测脑电图的 90 分钟日间睡眠（NAP）或清醒（NONAP）间隔期间应用。在 NAP/NONAP 事件后进行重新测试以评估巩固情况。行为结果表明，TMR 对两个组的运动表现均无影响。在大脑水平上，体感刺激在两个组中均引起了振荡活动的变化。具体而言，TMR 在 NONAP 组中诱导了 mu 波段的功率增加，在 NAP 和 NONAP 组中诱导了 beta 波段的功率增加。此外，TMR 在 NAP 组中引起了 sigma 功率的增加和 delta 振荡的减少。然而，这些 TMR 诱导的振荡活动调制均与运动记忆巩固的测量无关。总体而言，本研究结果表明，尽管体感 TMR 在学习后睡眠和清醒期间调节了大脑的振荡活动，但它不会在即时重测中影响运动表现。
