Veldman Menno P, Dolfen Nina, Gann Mareike A, Van Roy Anke, Peeters Ronald, King Bradley R, Albouy Geneviève
KU Leuven, Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, Leuven 3001, Belgium.
Leuven Brain Institute (LBI), KU Leuven, Leuven 3001, Belgium.
Cereb Cortex. 2023 Mar 21;33(7):3734-3749. doi: 10.1093/cercor/bhac304.
Increasing evidence suggests that reactivation of newly acquired memory traces during postlearning wakefulness plays an important role in memory consolidation. Here, we sought to boost the reactivation of a motor memory trace during postlearning wakefulness (quiet rest) immediately following learning using somatosensory targeted memory reactivation (TMR). Using functional magnetic resonance imaging, we examined the neural correlates of the reactivation process as well as the effect of the TMR intervention on brain responses elicited by task practice on 24 healthy young adults. Behavioral data of the post-TMR retest session showed a faster learning rate for the motor sequence that was reactivated as compared to the not-reactivated sequence. Brain imaging data revealed that motor, parietal, frontal, and cerebellar brain regions, which were recruited during initial motor learning, were specifically reactivated during the TMR episode and that hippocampo-frontal connectivity was modulated by the reactivation process. Importantly, the TMR-induced behavioral advantage was paralleled by dynamical changes in hippocampal activity and hippocampo-motor connectivity during task practice. Altogether, the present results suggest that somatosensory TMR during postlearning quiet rest can enhance motor performance via the modulation of hippocampo-cortical responses.
越来越多的证据表明，学习后清醒期间新获得的记忆痕迹的重新激活在记忆巩固中起着重要作用。在此，我们试图通过体感靶向记忆重新激活（TMR）来增强学习后立即进行的清醒（安静休息）期间运动记忆痕迹的重新激活。利用功能磁共振成像，我们研究了24名健康年轻成年人重新激活过程的神经关联以及TMR干预对任务练习引发的大脑反应的影响。TMR后复测 session 的行为数据显示，与未重新激活的序列相比，重新激活的运动序列的学习速度更快。脑成像数据显示，在初始运动学习期间被激活的运动、顶叶、额叶和小脑脑区在TMR期间被特异性重新激活，并且海马-额叶连接性受到重新激活过程的调节。重要的是，TMR诱导的行为优势与任务练习期间海马活动和海马-运动连接性的动态变化平行。总之，目前的结果表明，学习后安静休息期间的体感TMR可以通过调节海马-皮质反应来提高运动表现。
