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患者在 COVID-19 疾病 6 个月后持续的嗅觉功能障碍得到改善。

Persisting olfactory dysfunction improves in patients 6 months after COVID-19 disease.

机构信息

Medical Faculty, Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.

Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

出版信息

Acta Otolaryngol. 2021 Jun;141(6):626-629. doi: 10.1080/00016489.2021.1905178. Epub 2021 Apr 6.

Abstract

BACKGROUND

Smell disorders persist in about half of the patients with other symptoms of COVID-19 disease, but the exact duration of the symptoms is yet unknown. Especially, only a few studies used validated olfactory tests for this.

AIMS/OBJECTIVES: The aim of this study was to investigate how many patients with olfactory function impairment, which was detected in a validated olfactory test 3 months after COVID-19 disease, showed improvement in olfactory function after 6 months.

METHODS

About 26 patients with a PCR-confirmed, former COVID-19 disease, with an impaired olfactory function after three months, were included in the study. The olfactory function was evaluated with the sniffing sticks test, the taste function with taste sprays.

RESULTS

Smelling function improved in all but one patient (96%). All measured subitems, i.e. olfactory threshold, identification and discrimination of odours significantly improved. In the whole mouth taste test all patients showed normal taste function.

CONCLUSIONS AND SIGNIFICANCE

6 months after COVID-19 disease, olfactory function improves in just about all patients. Long-term measurements must investigate whether complete regeneration of the olfactory function will occur in all patients.

摘要

背景

大约一半 COVID-19 疾病其他症状的患者持续存在嗅觉障碍,但症状的确切持续时间尚不清楚。特别是,只有少数研究使用经过验证的嗅觉测试来进行研究。

目的/目标:本研究旨在调查在 COVID-19 疾病后 3 个月通过经过验证的嗅觉测试检测到嗅觉功能障碍的患者中,有多少患者在 6 个月后嗅觉功能得到改善。

方法

大约 26 名患者的 PCR 确诊、曾患 COVID-19 疾病,在三个月后嗅觉功能受损,被纳入研究。嗅觉功能用嗅棒测试进行评估,味觉功能用味觉喷雾进行评估。

结果

除了一名患者(96%)外,所有患者的嗅觉功能都有所改善。所有测量的亚项,即嗅觉阈值、气味识别和辨别能力均显著改善。在整个口腔味觉测试中,所有患者均表现出正常的味觉功能。

结论和意义

在 COVID-19 疾病发生 6 个月后,几乎所有患者的嗅觉功能都有所改善。长期测量必须调查所有患者的嗅觉功能是否会完全恢复。

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