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COVID-19 后嗅觉恢复的评估:横断面研究。

Assessment of olfactory recovery after COVID-19: cross-sectional study.

机构信息

Al Kasr Al Ainy School of Medicine, Cairo University, Cairo, 11562, Egypt.

出版信息

Eur Arch Otorhinolaryngol. 2024 Sep;281(9):4827-4834. doi: 10.1007/s00405-024-08646-5. Epub 2024 Apr 19.

Abstract

OBJECTIVE

This study aimed to evaluate recovery patterns of olfactory dysfunction among recovered COVID-19 patients, both subjective and objective, and correlate this recovery to the severity of the disease.

METHODS

The study recruited 200 patients and assigned them to two equal groups, one of them was a control group. The olfactory function of the study group was assessed via subjective and objective methods at baseline and then monthly for three months, with changes in smell function reported at each visit. These patients underwent chemosensory testing using the Sniffin' Sticks test and completed the validated Arabic version of the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS).

RESULTS

Olfactory dysfunction occurred on the first day of COVID-19 symptoms in 37% of participants. Subjective reports suggested smell recovery in 55% after 3 months, but Sniffin' Sticks showed only 1% with normal function, indicating persistent deficits in others. This study revealed smell recovery for 93% of participants (median 14 days), with most (58%) recovering within 2 weeks. No significant links were found between demographics, COVID-smell loss timing, and recovery speed.

CONCLUSION

Three months after COVID-19, many patients perceive smell recovery, but objective tests reveal shockingly high rates of persistent dysfunction. Further follow-up with objective tests is vital to assess the true burden and potential long-term effects of smell loss.

摘要

目的

本研究旨在评估 COVID-19 康复患者嗅觉功能的恢复模式,包括主观和客观评估,并将这种恢复与疾病的严重程度相关联。

方法

研究招募了 200 名患者,并将他们分为两组,每组 100 人,其中一组为对照组。研究组的嗅觉功能通过主观和客观方法在基线时进行评估,然后在接下来的三个月每月评估一次,每次就诊时报告嗅觉功能的变化。这些患者接受了 Sniffin' Sticks 测试的化学感觉测试,并完成了经过验证的阿拉伯语版嗅觉障碍问卷-否定陈述(QOD-NS)。

结果

37%的参与者在 COVID-19 症状的第一天出现嗅觉功能障碍。主观报告表明,3 个月后有 55%的患者嗅觉恢复,但 Sniffin' Sticks 测试仅显示 1%的患者嗅觉功能正常,这表明其他人的嗅觉功能仍存在持续缺陷。本研究显示,93%的参与者(中位数为 14 天)嗅觉恢复,大多数(58%)在 2 周内恢复。研究未发现人口统计学、COVID-嗅觉丧失时间和恢复速度之间存在显著联系。

结论

在 COVID-19 感染后 3 个月,许多患者感知到嗅觉恢复,但客观测试显示出高比例的持续功能障碍。进一步进行客观测试随访对于评估嗅觉丧失的真实负担和潜在长期影响至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c18/11393144/8e3bcd2ef539/405_2024_8646_Fig1_HTML.jpg

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