Curtius H C, Kuster T, Matasovic A, Blau N, Dhondt J L
Department of Pediatrics, University of Zurich, Switzerland.
Biochem Biophys Res Commun. 1988 Jun 16;153(2):715-21. doi: 10.1016/s0006-291x(88)81153-7.
Three unknown compounds present in the urine of a patient with mild hyperphenylalaninemia were identified to be L-erythro-7-iso-biopterin, D-erythro-7-iso-neopterin, and L-erythro-6-oxo-7-iso-biopterin. The newly identified pterins were named primapterin, anapterin, and 6-oxo-primapterin, respectively. Primapterin and anapterin are present in very low concentrations in every human urine, as well as in the liver of man and mouse, whereas 6-oxo-primapterin was detected in the patient's urine only. Substantial amounts of primapterin were excreted in the patient described. The metabolic origin of primapterin and anapterin is still obscure.
在一名轻度高苯丙氨酸血症患者的尿液中发现的三种未知化合物被鉴定为L-赤藓糖型-7-异生物蝶呤、D-赤藓糖型-7-异新蝶呤和L-赤藓糖型-6-氧代-7-异生物蝶呤。新鉴定出的蝶呤分别被命名为初蝶呤、反蝶呤和6-氧代-初蝶呤。初蝶呤和反蝶呤在每个人的尿液以及人和小鼠的肝脏中含量都非常低，而6-氧代-初蝶呤仅在该患者的尿液中被检测到。在所描述的患者中排出了大量的初蝶呤。初蝶呤和反蝶呤的代谢来源仍不清楚。
