Sobhani-Eraghi Amir, Motalebi Mohsen, Sarreshtehdari Siavash, Molazem-Sanandaji Borzooyeh, Hasanlu Zahra
Department of Orthopaedics Surgery, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Department of Medicine, Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
J Res Med Sci. 2020 Nov 26;25:104. doi: 10.4103/jrms.JRMS_983_19. eCollection 2020.
The inconsistent results of different studies regarding the prevalence of joint hypermobility (JH) or joint laxity in children and adolescents made us conduct a meta-analysis on the prevalence of JH in this age group.
We searched electronic databases including Trip, Scopus, Medline, Embase, PubMed, and Google Scholar; some Iranian databases including Iran Medex and Magiran; and Scientific Information Database to find studies in which the prevalence of JH in children and adolescents had been reported since January 1990 to April 2017. In this process, two researchers evaluated the articles separately while they were not aware of each other's method, and they extracted and matched the information.
Necessary data of twenty studies (15,097 boys and 6048 girls) were entered into this meta-analysis. The age range in these studies was 3-19 years. According to the meta-analysis conducted on the twenty studies, it was determined that the total prevalence of JH among children and adolescents was 34.1% (95% confidence interval [CI]: 33.3%-34.8%). Based on the results obtained from the studies, a significant heterogeneity (I index equals to 99,415 and ≤ 0.001) was shown, so we used random-effects model; moreover, the overall assessment of studies showed a statistically significant publication bias ( = 0.02). In total, the prevalence in girls was equal to 32.5% (95% CI: 31.4%-33.7%), and in boys, it was equal to 18.1% (95% CI: 17.2%-19.1%).
According to this meta-analysis, studies showed high heterogeneity, and the prevalence of JH in children and adolescents around the world was equal to 34.1% (95% CI: 33.3%-34.8%) in total, whereas it was higher in girls and lower in older ages.
不同研究关于儿童和青少年关节活动过度（JH）或关节松弛患病率的结果不一致，这促使我们对该年龄组JH的患病率进行荟萃分析。
我们检索了包括Trip、Scopus、Medline、Embase、PubMed和谷歌学术在内的电子数据库；一些伊朗数据库，如伊朗医学数据库和Magiran；以及科学信息数据库，以查找自1990年1月至2017年4月报告儿童和青少年JH患病率的研究。在此过程中，两名研究人员在彼此不知情对方方法的情况下分别评估文章，并提取和匹配信息。
二十项研究（15097名男孩和6048名女孩）的必要数据被纳入该荟萃分析。这些研究中的年龄范围为3至19岁。根据对这二十项研究进行的荟萃分析，确定儿童和青少年中JH的总患病率为34.1%（95%置信区间[CI]：33.3% - 34.8%）。基于研究获得的结果，显示出显著的异质性（I指数等于99415且P≤0.001），因此我们使用随机效应模型；此外，对研究的总体评估显示存在统计学上显著的发表偏倚（P = 0.02）。总体而言，女孩中的患病率为32.5%（95%CI：31.4% - 33.7%），男孩中的患病率为18.1%（95%CI：17.2% - 19.1%）。
根据这项荟萃分析，研究显示出高度异质性，全世界儿童和青少年中JH的总患病率为34.1%（95%CI：33.3% - 34.8%），而女孩中的患病率较高，年龄较大者中的患病率较低。
