Jazayeri Maryam, Moradi Yousef, Rasti Arezoo, Nakhjavani Manouchehr, Kamali Mahboobeh, Baradaran Hamid Reza
Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology, School of Public Health, Iran University of Medical Science, Tehran, Iran.
Med J Islam Repub Iran. 2018 Sep 8;32:83. doi: 10.14196/mjiri.32.83. eCollection 2018.
Vitamin D deficiency is related to rickets in children, and it can increase the risk of osteoporosis in adulthood. The aim of our study was to estimate the prevalence of vitamin D deficiency among healthy Iranian children and adolescents. Vitamin D levels less than 20ng/ml and between 20 and 30ng/ml was considered as vitamin D deficiency and insufficiency, respectively. Relevant observational studies evaluating the prevalence of vitamin D deficiency through 1 January 1990 to 28 Dec 2016, were searched in several electronic databases including Iran-Medex, Scientific Information Database (SID), Irandoc, PubMed and NLM Gateway (for MEDLINE), Web of Science, and Scopus with no restriction on language. Only full-text articles were used for data extraction and synthesis after considering the inclusion/exclusion criteria. 11 studies included; the data of four studies of Iranian newborns were withdrawn because of their high heterogeneity. The prevalence of vitamin D deficiency in Iranian boys and girls were 35% (CI 95% 34-37) and 61% (CI 95% 60-63), respectively. The prevalence of vitamin D insufficiency in Iranian children and adolescents was 31% (CI 95% 30-31). It seems that the prevalence of vitamin D deficiency is very high among Iranian children and adolescents. The present findings could provide practical information for healthcare decision makers.
维生素D缺乏与儿童佝偻病有关，并且会增加成年后患骨质疏松症的风险。我们研究的目的是评估伊朗健康儿童和青少年中维生素D缺乏的患病率。维生素D水平低于20ng/ml和在20至30ng/ml之间分别被视为维生素D缺乏和不足。通过检索包括伊朗医学索引（Iran-Medex）、科学信息数据库（SID）、伊朗文献数据库（Irandoc）、PubMed和NLM网关（用于MEDLINE）、科学引文索引（Web of Science）和Scopus在内的多个电子数据库，查找1990年1月1日至2016年12月28日期间评估维生素D缺乏患病率的相关观察性研究，对语言无限制。在考虑纳入/排除标准后，仅使用全文文章进行数据提取和综合。共纳入11项研究；由于异质性高，四项关于伊朗新生儿的研究数据被排除。伊朗男孩和女孩维生素D缺乏的患病率分别为35%（95%置信区间34 - 37）和61%（95%置信区间60 - 63）。伊朗儿童和青少年维生素D不足的患病率为31%（95%置信区间30 - 31）。伊朗儿童和青少年中维生素D缺乏的患病率似乎非常高。目前的研究结果可为医疗保健决策者提供实用信息。
