Saadouli Dorsaf, Ammari Lamia, Ben Mansour Khaoula, Yahyaoui Yosra, Aissa Sameh, Mohamed Ali El Afrit, Yahyaoui Salem, Tiouri Hanene
Department of Ophthalmology, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Department of Infectious Diseases, La Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
South Afr J HIV Med. 2021 Mar 19;22(1):1193. doi: 10.4102/sajhivmed.v22i1.1193. eCollection 2021.
Ocular involvement is a common complication of human immunodeficiency virus (HIV). Knowledge about this topic in Tunisia is limited.
To investigate ophthalmic manifestations in patients living with HIV in Tunisia.
This was an observational study, performed between January 2007 and December 2016. We included patients with ocular disorders related to HIV. The data were recorded retrospectively from chart review.
Amongst 98 people living with HIV (PLWH), 36 participants (55 eyes) had ocular manifestations. The mean age was 32.2 ± 5.6 years. Twenty-four patients were men and 12 were women. The mean value of CD4+ T-cell count was 156.5 ± 4.2 cells/µL. Bilateral lesions were found in 19 eyes. Best corrected visual acuity was better than 6/12 in 36 eyes. The most common ocular finding was dry eye syndrome (22%), cotton-wool spots (20%) and retinal haemorrhage (16%) followed by cytomegalovirus (CMV) retinitis (9%), anterior uveitis (7%), toxoplasmosis (4%) and tuberculosis retinochoroiditis (7%) Herpetic keratitis (5%), Herpes zoster ophthalmicus (2%) and syphilitic chorioretinitis (2%). Papilledema was found in three eyes (5%). Panuveitis was observed in four eyes (7%): three of them were associated with chorioretinal toxoplasmosis, syphilitic chorioretinitis and CMV retinitis. The fourth was attributable to immune recovery uveitis. A CD4+ T-cell count of ≤ 200 cells/µL was found to be an independent risk factor for developing posterior segment manifestations.
Various ophthalmic manifestations were observed in PLWH. The most common lesion was retinopathy. Ocular involvement can be serious leading to poor visual prognosis, which requires close collaboration between the ophthalmologist and infectious disease physician.
眼部受累是人类免疫缺陷病毒（HIV）的常见并发症。突尼斯关于这一主题的知识有限。
调查突尼斯HIV感染者的眼部表现。
这是一项于2007年1月至2016年12月期间进行的观察性研究。我们纳入了与HIV相关的眼部疾病患者。数据通过回顾病历进行回顾性记录。
在98名HIV感染者（PLWH）中，36名参与者（55只眼）有眼部表现。平均年龄为32.2±5.6岁。男性24例，女性12例。CD4 + T细胞计数的平均值为156.5±4.2个细胞/微升。19只眼发现双侧病变。36只眼的最佳矫正视力优于6/12。最常见的眼部表现是干眼症（22%）、棉絮斑（20%）和视网膜出血（16%），其次是巨细胞病毒（CMV）视网膜炎（9%）、前葡萄膜炎（7%）、弓形虫病（4%）和结核性视网膜脉络膜炎（7%）、疱疹性角膜炎（5%）、带状疱疹性眼炎（2%）和梅毒性脉络膜视网膜炎（2%）。3只眼（5%）发现视乳头水肿。4只眼（7%）观察到全葡萄膜炎：其中3只与脉络膜视网膜弓形虫病、梅毒性脉络膜视网膜炎和CMV视网膜炎有关。第4只归因于免疫重建葡萄膜炎。CD4 + T细胞计数≤200个细胞/微升被发现是发生后段表现的独立危险因素。
在PLWH中观察到各种眼部表现。最常见的病变是视网膜病变。眼部受累可能很严重，导致视力预后不良，这需要眼科医生和传染病医生密切合作。
