Lala Vikash G, Bobat Bilal, Haagensen Mark, Kathan Prakash, Mahomed Adam
Department of Gastroenterology, Faculty Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.
Department of Gastroenterology, Faculty Internal Medicine, Wits Donald Gordan Medical Centre, Johannesburg, South Africa.
SA J Radiol. 2021 Mar 18;25(1):2016. doi: 10.4102/sajr.v25i1.2016. eCollection 2021.
Metronidazole is a widely used antibacterial and antiprotozoal agent for a number of conditions. Whilst its more common gastrointestinal side effects are well known, neurotoxicity remains under-recognised. Both central and peripheral neurological side effects have been described. This report describes a case of radiologically confirmed metronidazole-induced cerebellar ataxia in a cirrhotic patient with a review of the literature. Awareness of this side effect is essential for prompt recognition as early drug withdrawal leads to resolution in the majority of cases.
甲硝唑是一种广泛用于多种病症的抗菌和抗原虫药物。虽然其较常见的胃肠道副作用广为人知，但神经毒性仍未得到充分认识。中枢和外周神经方面的副作用均有描述。本报告描述了一例经放射学证实的肝硬化患者甲硝唑诱发的小脑共济失调病例，并对相关文献进行了综述。认识到这种副作用对于及时识别至关重要，因为在大多数情况下，早期停药可使症状缓解。
