Clements Adam
Aspirus Wausau Hospital, Wausau, Wisconsin,
WMJ. 2017 Dec;116(5):221-223.
This report describes the case of an 83-year-old woman who was admitted to a hospitalist service with weakness and falls. She was transferred from an outside facility where she was treated with 3 courses of metronidazole for diagnosed Clostridium difficile colitis and presumed reoccurrences. Magnetic resonance imaging (MRI) demonstrated T2 enhancement of the dorsal pons and dentate nuclei consistent with metronidazole-induced encephalopathy. Her metronidazole was stopped and her symptoms resolved. This condition is rare, poorly understood, and causes reversible changes in the brain that are detectable through T2-weighted MRI. It will need ongoing study with current widespread use of metronidazole.
本报告描述了一名83岁女性的病例，她因身体虚弱和跌倒而入住内科病房。她是从外部机构转来的，在那里她因诊断为艰难梭菌性结肠炎及推测的复发接受了3个疗程的甲硝唑治疗。磁共振成像（MRI）显示脑桥背侧和齿状核T2信号增强，符合甲硝唑诱发的脑病。她的甲硝唑治疗被停用，症状得到缓解。这种情况很罕见，了解甚少，会导致大脑发生可逆性变化，可通过T2加权MRI检测到。鉴于目前甲硝唑的广泛使用，需要持续进行研究。
